Observationes ex vaccinatione in Medelpadia et Jemtlandia collectæ, quas cons. exp. Facult. Med. Ups. præside Petro Afzelio ... pro gradu medico p. p. Petrus Rissler ... Jemtlandus, in audit. Gustaviano die XVI febr. MDCCCXI.

OBSERVATIONES EX VACCINATIONE

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M EDELPADIA ET JEMTLANDIA COLLECTÆ

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M. D. P H ET CH. M. R El C H1KURGI CÆ DI RECTORE SUPREMO E T M E D I C I N E T H E O R E T . ET PKACT P R OF E S S OR E REG. ET ORD.

REGG. AC A D D . S C I E N T ET PRO RE MI LI T. HOLM. SOC1E T T . KEGQ. S C I E N T . U P S A L . E T MEDIC. E D1NB. ATQl ' E S O C I E T T .

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O B S E R V A T I O N E S e x V A C C I N A T I O N S i n M E D E L P A D I A e t J E M T L A N D I A C O L L E C T Æ . V / b f e r v a t u m c u m e f t , d i v e r f a s cæli p l a g a s ad m o r b o s n o n n u l l o s n o n t a n t u m i m m u t a n d o s , v e r u m e t i a m , q u a m v i s d i v e r f i t a s h æ c n o n e x al iq ua m a j u s c u l a , i n t e r d u m n u l l a , o r t a eft d i f f e r e n t i a l a t i t u d i n i s , p e n i t u s r e p r i m e n d o s i ) , v a l e r e , c e n f e m u s o b f e r v a t i o n e s q u a s d a m d e V a r i o l i s v a c ­ c i n i s , e x vi f u a , e u m , q ui illis f u e r i t a f f c & u s , a v a r i o l i s , m o r b o , q u e m n o v i m u s , m a x i m e p e f t i f e r o , t u e n d i , no ti s, A

Me-i ) I n ter m orbos incognitos in Jemtlandia n um eratur febris inter­ m itte n s V ide ; S a m lin g a r till eu B e fk rifn in g ô fver N o r rla n d . A n d r a S a m lin g e n om g få m tla n d 3f A b r AßRAH:fon H ü l p h e r s . W e fte rS s , 3775. pagg- 29 * 69. — Ullum indigenam Jemtlandiæ in illam febrim d om i illapfum esfe non adhuc confiât et a d v e n æ , illa la b ora ntes, bre­ v i , absque ulla m edicina, fani fiunt (E x litteris Medici Caftrenf. P ri­ m är. L egion. Jem tlandicæ J o n æ G e s t r i c h , 1810 exaratis). N ec S carlatin a, quantum f c ia m , in Jemtlandia adhuc invaluit. Febrem in­ te rm itte n te m in W e ftro g o th ia qudque olim rarum fuisfe morbum mini narravit Celeberr. P r æ s e s , qui in aetate praetextata totam viciniam ad f a m u l u m , hac febri (K alian vulgus ibidem vocat) la b o ra n tem , quid in- foliti vifendi gratia affluxisfe viderat. Tusfim itidem convulfivam, non mulris abhinc a n n i s , primum iftuc a liberis, ex illa convalefcentibus e t p a re n tes nb Uplandia iter facientes comitantibus i n v e f t im fuisfe, Idem Ct*l. V i r asfieveravit. Plures plagae feptentrionalis Provincias a febri in te r m itte n te liberas esfe le g im u s , "id* fis: D agbok ô fv e r en Re/a ige­ n om de u nder S to ra K o p p a rb erg s H ôfdingedôm e lydande Låhn och D a la r n e , Sr 1757 af A b r . A ßRAHifnn H ü l p h e r s W efterSs 1762 p. 4 ^ 2 — E ju s d . S a m lin g till en Resb f k t f n i n g ô fv er N o r rla n d t: ß a S a m i. Om M edelpad W e fte rS s , 1771. pagg. 3 6 , 8 6 y:d je Sam i. om H erjedalen. W e fterS s. 1777. p. 3 6 . — D tsfert. H tJlorica de efficacia C hm atum & c . a J a c F r N e i k t e r . P IV . p. 49. — N ordtjches A r ­ chiv f ü r N a tu rk u n d e t A r z n e y w is fe n jc h a ft, & c. 3?ter B, 1 St. Kopen­ h a g e n , 1802. p. 9 $ .

M e d e î p a d i æ fa &a s e t J e m t l a n d i æ , f ub c æ l o t u m o b i n d o - l e m j a m d i d t a m t u m g r a n d i o r e m pol i e l e v a t i o n e m 2) in» f i g n i , p r o p t e r c o m p a r a t i o n e m , quae c u m v a r i o i i s v a c c i n i s i n t e r r i s c a li d i o r i b us 3) ml fi tui q u e a t , ad p e n i t i o r e m e a r u m c o g n i t i o n e m esfe a l i q u a n t u m a d j u t u r a s . H a c m e n t e fpe- r a v i a d n o t a t i o n e s illas d e var . v a c c , p a u c a s q u a m v i s e t m a n c a s , q u a s f ub v a c c i n a t i o n e , j usfu R c g . C o l l e g i i M e d i ­ ci e t i m p e n f i s p u b li c i s a n n o m d c c c v M e d e î p a d i æ a m e p e r a & a , q u a m q u e d e i n a n n o m d c c c v i n e q u e j us fu s n e q u e p u b l i c a p e c u n i a a d j u t u s f p o n t e m e a J e m t l a n d i æ c o n t i ­ n u a v i , f e c e r a m , n o n i n u t i l e m esf e e x h i b i t u r a s m a t e r i e m d i s f e r t a t i o m s A c a d e m i c æ , e x p r æ f c r i p t i s p r o G r a d u M e ­ d i c o e d e n d æ . P r a e t e r e a , c u i n e x R e g i a M a j e f t a t e , f ua fu R e g . C o l l e g i i M e d i c i , et v a c c i n a t i o n e m i n hisce locis p e r - a d a m , bis p r a em i o 4) fui o r n a t u s , e r i t m i h i ipfi in v o ­ l u p t a t e , h a c o c c a f i o n e r a t i o n e m a l i q u a m , q u a m v i s n o n q u æ f i t a m , t u m b e n e v o l e n t i a e R e g . C o l l e g . M e d i c i j u v e n i m i h i n e c d u m e x p e r t o p r æ f t i r æ , t u m fubl idi i e x æ r a r i o p u b l i c o a d h u n c p e r u t i l i s l i m u m f i n e m c o l l a t i , r e d d e r e » A n n o m d c c c v q u a r t o d i e i d u u m J un ii i n c e p i M e d e C p a d i æ i n par oecia T o r p v a c c i n a t i o n e m , v i r u s u t e n s v a r i o -l a r u m

2) Medelpadia et Jemtlandia inter 62*, 8' e t 65% 6' b tit u d fe- pte ntrio n. jacent. V accin ationem etiam propius polum cum luccesfu in- ftitutum fuisfe, feil, in Finm arkiæ infula W a d s ô fub 70 grad. fita, ex N :o 9 In rik e s T id n in g a r 1805 novimus.

3) R e vaccinatione in India orientali p e r a f t a , p ræ te r Nobilißf. J o H . a C a r k o (vide E j u s d e m : H iftoire de ta V accination en T u r ­ q u ie , en Grece et a u x In d es O rientales. V i e n n e , 1804 ) foripfit Dr. A n d e r s s o n ; vid e : The London Medical and S u rg ic a l S p ectator. i g o g , N :o II. p. 110. — In Infula Ceylo n T h o i v t a s C h r i s t i e Med. S u p er.

Intend. G en era l., Tbid. N :o V. p. 431 et N :o V III. p. 20 7 - In B r a

-filia Dr. J A. B a r r a s o , Ibid. N:o V I I I , p. 292. Cfr. M ed. C hir» Z e i t . 1807* N:o I

l a r u m v a c c i n a r u m , q u o d b i n i s h e b d o m a d i s a n t e H o l m i a e i n D o m o p r o v a r i o l i s i n f e r e n d i s , i n t e r l a m e l l a s v i t r e a s , a b aë r i s a c c e s f u ut a r c e r e t u r , f e c u n d u m r e g u l a s arri s c o n - j u n t t a s , i p f e m i h i a c q u i f i v e r a m . U n i u s t a n t u m e x t r i b u s u n a f u m t i s v i t r i s f ui t efficax v i r u s , f e d e x v a r i o l i s illis v a c c i n i s , q u a s h o c c e v i r u s a p u d u n u m i n f a n t e m p r o v o c a ­ b a t , h a u f fa eft m a t e r i e s , q u a r e li qui in parœcii-s T o r p , S e l l å n g e r , T u n a e t N j u r u n d a n u m e r o c c c x v i i i d e i n d e f u e r u n t affetti*, n e c o b f e r v a r i p o t u i t , i n f i t i o n e p e r m a t e ­ r i a m r e c e n t e m , q u i q u i d e m c a f us e x u n o f u b j e t t o a d alte­ r u m fuit f r e q u e n t i s f i m u s , f a t t a , v a r i o l a s v a c c. f p e c i e , f o r ­ m a a t q u e m o d o c o r p u s a f f i ci e n d i , a l i t e r ac in i n i t i o fe h a ­ b e r e . U t r u m v a r i o l æ v a c c i n a e , e x v i r u s ortae n o n r e c e n t i , h . e. q u o d l o n g i u s t e m p o r i s f p a t i u m a u t i n t e r v i t r a , a u t a l i o m o d o fuit c o n f e r v a r u m , f e m p e r r a r d i u s e r u m p a n t e t f e fe f o r m e n t , cui f f a t u e n d o e t p e r a n a l o g i a m e x o b f e r v a - t i o m b u s in v a r i o l a s i n f u i t i a s 5) e t p e r c o m p a r a t i o n e m c u m illis, q u i m a t e r i a r e c e n t i m o d o f u p r a d i t t o f u e r u n t i n f e t t i , n o n n u l l æ e x f f i t e r u n t caufae, a n e t i a m a d t a r d i o ­ r e m e r u p t i o n e m i pf a f u b j e t t i i n d o l e s a ë n s q u e t e m p e r i e s i n f e r i o r c o n t r i b u a n t , p l u r e s d e f i d e r a n t u r e t , q u a m q u a s e g o i n f t i r u e r e p o t u i a c c u r a t i o r e s o b f e r v a t i o n e s . Ill as v e r o v a r i o l a s v a c c i n a s , quer x : m o e t x r . m o d i e f o r m a b a n t u r , d e r e l i q u o fuisfe m s r u r i u s e r u m p e n t i b u s a d f i m i l e s , e t infi- t i o n e m a b h i s c e v a r i o l i s t a r d i u s e r u p t i s v a r i o l a s e f f ec is f e

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va-5 ) B erå ttelje om K o p p o rs y m p a n d e , ö fverU m n a d till H o g loßige K ongl. S u n d h e ts Commtsfionen af D a v i d S c h u l t z . M. D. S to c k h . 1VIDCCLV1, p. 46. — B e r i t t d je r inläm nade till K ongL Collegium M e­ d ic u m , r ö r a n d e M e d ic in a l- W e rk e ts tillflå n d i R i k e t , &c. S to ck h . 1765, p 15» n 8 . - J o A N N i s A n d r e æ M u b r a y H iß o ria ln fttio n is h a ­ r io la ru m in S v e c ia , & c . Gottir gae 1 7 6 7 , p. 106 Cfr E ju s d . Obfer- vationum et A n in ta d v e rfto n u m J u p tr h a r io la r u m infitione S a tu r a mt in

v a c c i n a s f o ï i t o t e m p o r e f o r m a t a s , c e r r u m eft a d m o d u m e t f i r m u m . C u i o b f e r v a r i o n i c o n f e n t a n e a m v i d i m u s e x ­ p e r i e n t i a m C e l e b b . V i r o r u m , Jo h. Er n s t Bl a c h e t e t Er i ci Hö g b e r g, qui v a c c i n a t i o n e m V e r m e l a n d i æ p e r e g e r u n t 6). M i n o r e s a u t e m n e r e c e n f e a m u s e j u s m o d i a (olit o a b e r r a ­ t i o n e s , d i s f u a d e n t e t a r & i o p e r i s n o f t r i l imires et e x i g u a i n d e h a u r i e n d a u t i l i t a s ; p o t i u s i g i t u r , v a c c i n a t i o m s in J e m t - l a n d i a i n i t i o e t p r o g r e s f u ac cu r a ti us p a u l l u m e n a r r a t i s , ftu- d e b o p r o t e n u i t a t e e x p e r i e n t i a e m ea e , d e f c r i p t i o n e m f i ft er e d e c u r f u s v a r i o l a r u m v a c c i n a r u m u t i l lum faepisfime o b f e r - v a v i , e t d e i n n o n alio a d f t r i £ l u s o r d i n e q u a m f o r t u i t a e a ­ r u m p e r f c r i p t i o n e , a d f e r r e t o t o b f e r v a c i o n e s , q u o t a n - g u f t a d i s f e r t a t i o c a p i a r . I n f a n t e s , q u i b u s in p a r o e c i i s O v i k e n , R ô d ô n r H a m ­ m e r d a h l , S u n n e e t L i t , ce tt . J e m t l a n d i æ a n n o m p c c c v i v ar iol ae vaccinae i n f e r e b a n t u r , e r a n t n u m e r o c d l x x x v i. I n d i c e s e x a & o s v a c c i n a t i o n i s e t illic e t M e d e l p a d i æ a m e habi tae R e g i o C o l l e g i o M e d i c o t r a d i d i . J en tlandiae v e ­ r u m j a m a n n o m d c c c i v v a r i o l a s i n f e v e r a t M a g . Pe t r u s G e r d l u n d n u n c t e m p o r i s C o m m i n i f t e r i n H e m ô f a n d i a ,

t u m A d j u n f t u s P a f t o r i s i n R ô d ô n , c u r a A d j u n & i M e ­ d i e . F a c u l t . U p f a l . D o & o r i s Ze t t e r s t r ô m p r æ f c r i p t i s

n e c e s f a r i i s , f c al pel lis e t f o r m u l a D i a r i i V a c c i n a t i o n i s i n- f t r u £ t u s , p r o s p e r e e t feli cit er q u a t t u o r paroeciae f u æ i n ­ f a n t i b u s , at aliis d e t e n t u s n e g o t i i s p e r g e r e n o n p o t u i t , e t v i r u s v a r i o l a r , v a c c i n , m o r e f o l i t o I n t e r v i t r a r e f e r v a t u m * q u o d f u b æ f t a t e a n n i m d c c c v a d e u m m i i e r a m , ille v e r o o b n e g o t i a i n t e r v e n i e n t i a n o n f t a t i m uf us e r a t , n o n p r o - c e s f i t , e t c u m S a c e r d o s ille m o x t u m H e r n c e f a n d i a m v o ­ c a r e t u r , f ubf ti ti t i n J e m t l a n d i a v a c c i n a t i o , d o n e c , u t fu- p r a d i £ l u m » a n n o m d c c c v i e a m r e d i n t e g r a v e r i m . Sv e n o G r ö n d a h l Phil. M a g . e t S. M . A d j u n £ t u s i n R ô d ô n , q u i

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m e in i n f i t i o n e o c c u p a ru m ali q uo tie s i n f p e x e r a r et pudula- r u m f o r m a t i o n e m et i n d o l e m v a r i o l a r u m ex pu d u lis infi- t a r u m o b f e r v a v e r a r , a p u d a n i m u m d a t u e b a t in fubjeftis no- v i s , e x m e i s p i æ c e p t i s , v a c c i n a n d i o p u s co n tinuar e. A n ­ n o M D C C c v i i i _{bis ex H o l m i a fibi p a r a b a t cu ra M e r c a t o r i s} N i e . H o l m l u n d v i i u s v a r i o l . v a c c i n , i n t e r vitra r e c o n d i ­

t u m , n e c t a m e n ulla v ic e fuccesfit infirio; p o d e a fuafu n u p e r l au da ti D o d t o r i s Ze t t e r s t r ö m, u t , d o n e c v i r u s r e ­ c e n s c o m p a r a r e r u r , t e n t a r e t , quae l o c o r e c en tis virus p ro - p o f i r æ f u e r e 7 ) , cr uf tas v a r i o l a r u m v a c c i n a ru m mollitas, e x p e r i m e n r u m i n d i t u i t cu m c r u d i s a p r o x i m e laudaro D o - t t o r e m i s f i s , q ui illas ex infanti v e r e variolis vaccinis af- f e £ t o , f u m e n d a s c u r av it. _{E x h i s c e r e ct e et e x p r æ f c r i p t o} m o l l i t i s fe c it i n f i t i o n e m t ri b u s i n f a n t i b u s , q u o r u m in d u o ­ b u s a p p a r e b a t v : t o et v i : t o die in pun&urae locis r u b o r c u m p u d u l a , q u æ i x : n o et x : m o d i e c r u d a m coepit f o r ­ m a r e , c r u d i s v a r i o l a r u m va c ci n, a l i q u a n tu m q u i d e m fimi- l e m , n o n t a m e n r o t u n d a m a d e o et laevem, et q u a m q u a m r u b o r c i r c u m c i r c a di e x u r m o a c c r e v e r i t , n o n ta m en e r a t v i v i d a illa e t folita a r e o l a ; di e x i v : t o d e d e r a t h æ c , c r u d a q u e e r a t a r e f a & a , q u a p r o p t e r ce n fu i t i n fi tio ne m illam f r u d r a - n e a m et d e c r e v i t t e m p o r e o p p o r t u n o ufu v iru s recentis v e r i t a t e m o p i n i o n i s h ujus e x p l o r a r e , q u o d j a m d u d u m fa- £ l u m n o s d o c e t , v e r a s var iolas va c c i n a s tum p r i m u m p r o - diisfe. _{I n u n i c o i n d t i o n i s p u n £ t o in fa n t i s tertii a p p a ru it} v a r i o l a m a g n a , q u æ u t in d u o b u s j a m r e c en liri s, c o n fv e- t a m etfi d e f i d e r a b a t r o t u n d i t a t e m , r u b o r e m t a m e n circ um

7) _{In rike s T id n in g ar N:o 122, Sr 1805 — P ra llrifche Beobachtun­} g en Uber die Im p fu n g dev K uhpocken, v o n J a m e s B r y c e . A u s dem E nglifchen ü b erfetz t, und mit A nm erkungen begleitet v o n F r i e d r . G o t t h k l f F r i e s e _{— N achricht ueher die WxYkJamkeit u n d N ü t z -}

tichkeit d i r Kuhpocken - Im p fu n g m it dem Schorfe. Von G e o r g U e -

-c l a r i o r e m e t d i u t u r n i o r e m -c u m -c r u f t a , -c i r -c i t e r f e x h e b d o ­ m a d a s a d h a e r e n t e , h a b e b a t . Inf it io n o v a e j u s d e m f u bj e£ li c u m v i r u s r e c e n t i , n o n f u c c es f i t , a d e o ut inlîrio fa£ta e x c r u f t i s hac v i c e i d e m v i d e a t u r ef f ec is f e , ac v a r i o l æ v a c c i ­ nae p e r v i r u s r e c e n s infiræ. V e r i t a t e m t a m e n a c c u r a t i u s q u æ f i t u r u s i t e r u m d a t a r e c e n t i s m a t e r i e i c o p i a , e j u s d e m i n f a n t i s e x p e r i e t u r v a c c i n a t i o n e m . V i r u s i d , q u o d t a n d e m p r o c e s f i t , cujus u f u i t e r a t a ifta in i n f a n t i b u s , af f £tis m a ­ t e r i e e x cr uf t is f u m t a , i nf t i r u e r a t e x o e r i m e n t a , e x H o l m i a , c u r a v i r g i n i s Ch a r l. Be r l i n P r æ p o f i r i in R ô d ô n Filiae, t u m H o l m i æ d e g e n t i s , ad e u m e r a t mi sf um. I n p a r o e ­ c i is R ô d ô n , A s p å s , F r ô s f ô n e t L i t p e r h o c v i r u s v a r i o ­ las i n f e v i t i n f a n t i b u s c x x ï n , c uj us v a c c i n a t i o n i s D i a r i u m a d m e m i s f u m , u t p o t e a u t h e n t i c a n o n m i n u s q u a m h o n o ­ r ifica cl auf ul a i n f t r u £ t u m 8 ) , p e r v e l l e m , ad e x e r a p l u m e o r u m , qui e j u s m o d i c a t a l o g o s , c u m infit io v a r i o l a r u m p r i m u m in S v e c i a i n f t i r u e r e t u r , ï n f i r o r i s et p a r e n t u m , n o- î l r a t i b u s fuis i nf i gni d o c u m e n t o p r æ f t a n t i u m , d e b i t a m i n l a u d e m p u b l i c i j u r i s f e c e r u n t 9 , h i c i n f e r e r e , c u m v e r o o p e r i s hu ju s a n g u f t i æ n o n f i n u n t ut a d f e r a t u r . et ille i p f e , p o l l q u a m v a c c i n a t i o n e m ul t er i u s c o n t i n u a v i t , R e g i o C o l ­ l e g i o M e d i c o o l i m id f o r f a n c o m m u n i c a b i t , t a n t u m e x a d j u n f t i s ejus o b f e r v a t i o n i b u s , quas q u i d e m g a u d e n s v i d e o m e a s fua fide c o n f i r m a r e , u n a m a l r e r a m v e a d f e r a m . ° I n

8 ) ” Att Hr. Magifter S v e n G r ö n d a h l , fâfom fôrefkrifvit ftSr, vaccinationen hSrftädes nitifkr och berômligen verkftSllt; in ty g a r

IVIag. B e r l i n Kongl Hofpred. och Proft. A b r . A g e r b e r g C o m - m irifter. O l o f O l o f s o n i U n d r o m, Kyrkovärd.”

9 ) P ro vin cia l D offiorernas till K ongl. Collegium M edicum in le m - noide B e r å tte lfe r , & c. Sto ckh 1761 p a^g . 8 3 , 8 6 . 88- — Ber& tteU J t r , inläm nade till Kongl. Collegium M ed ic u m . &c. Stockh. 1 7 6 5 - p a g g . 8 , 2 5 2 , 258- — B e rå tte lfe r til' R ikfens H o g h flig e S tå n d e r r ö r a n d e M edicinal - IP erkets tillfiå n d i R iket. Upfala 1769, pagg. 446, 4 5 1 , & c.

” I n i n f a m i b u s mac e ll is n o n p ' u r e s , q u a m fuer e p u n - {V.rae _{p r o d i e i u m p u ü u l æ , a p u d o b e l o s v e r o et p l eni ori s} h _{a u s e t i a m in vicinit. te loci infiririi quaedam p r o v e n e r e ,} q u a r u m n o n i udae a v i r i o l i s v a c ci n is , i m p r e s f i o n e m c e n ­ t r i , quae d e f u i t , fi e x c e p e r i s , p a r ù m a b l u d e r u n t . In m a ­ c r i s e r u p t i o T e m p e r fere t a r d i o r , n o n ante v u t u m , v i i r m u m e t v n i r v u r n d i e m , n e c a r e ola circirer x n : m u m et x n n m u m a p p i r e n s , i a m r u b i c u n d a f u ir, q u a m in pl en i s , illa m a t u ­ r i u s q u o q u e o r n a t i s . "

” Q u o s , S ir i o ae ft uant e, va r iolis vaccinis i m b u i , pejus fe h a b u e r e et puft ul ae, m a t u rius jufto exortae, a f o r m a et

d e c u r f u _{v e r a r u m m u l t u m a b l u e r u n t 10)."} ” A p u d p l u r e s i n f a n t e s , n e ullus q u i d e m r u b o r vel p u - ftula a n t e d i e m v n : m u m aut v i n : v u m a p p a r u e r e , et in p l e r i s q u e areolae et crullae p e r x x v , x x x ad x l di es e t q u o d e x c u r r i t , m a n f e r u n t / ’ I n u t i li t at e v a c c i n a t i o n i s p u bl ice et p r i v a t i m ad c a ­ p r u m v u l g i p r o p o n e n d a , eriamfi fedulus fu i , p r o g r e s f u s t a m e n e ju s prae i n d o l e n t i a et o p i n i o n e p a r e n t u m , a d e o l e n t i f u e r e , u t , nifi p u b l i c a q u a d a m , cu m occafio infe­ r e n d i n o n d e f u i t , i n j u n g a n t u r auctor ita te n ) , illam a m ­ p l ect i ,

1 0 ) _{Hujus annotationis fidem facit frequens Cei P r æ s i d i s ex­} perientia. _{Rufticorum fcilicet infantibus in proximitate fontis falutaris,} qui S S tr a audit, ibidem valetudines acidulis utentium regens, utilisfi, m æ rei promovendae gratia variolas vaccinas gratuito inferendo, quos p e r calidisfimam ælb.tem im buit, quas pro genuinis habene non licuit, accepisfe , fæpius obfervavit. Ex E ju sd Praeleft. publicis.

11) Cei. P r æ s k s _{publicis Leftionibus hanc rem pertra&ar« huic}

fini utile habuit o btinendo, lege fi farciretur, ut quadrimus quisque, qui vaccinationem non fubivit, in vafariis (Mantalslângden) inferibere- t u r et p r o u t adultus cenfum p en d e ret, donec variolis »accinis defun- f t u s fuerit-,4 cum rurfus ad folitum, legibus praefinitum, tempus cenfw liberaretur.

p l e f t i , f æ c u l u m a n t e t r a n s i v e r i t , q u a m in a n n u i s m o r i e n - t i u m d i p t y c h i s i n f a n t e s , e x v a r i o l i s e x f t i n £ t o s , i n f c r i b e n d i p o r r o n o b i s n o n fit nec es fi tas .”

Q u æ M e d e l p a d i æ C ei . A s f e s f o r J o H . N o r æ u s, e t j e m t - landiae M e d . C a l t r e n f . P r i m ä r . J o n G e s t r i c h in r e m v a c -

c i n a t i o n i s e g e r i n t , q ua e que illis l icui t o b t e r v a r e , e r u n t q u i ­ d e m i n r e l a t i o n i b u s e o r u m ad R e g . C o l l e g i u m M e d i c u m c o m m e m o r a r a et d e i n c u r a l audati C o l l e g i i C u l t o r u m fci- entiae M ed ic a e i n u f u m e d i t a , f i cque h a r u m P r o v i n c i a r u m H i f l o r i a v a c c i n a t i o n i s , j a m i n c e p t a , p e r f i f t i o r e x i b i t ec n u m e r i s a b f o l u t i o r . S e d a d p r o p o l i c u m r e v e r t a r . P o f t q u a m i n f i t i o n e , (lanceolae a p i c i s , v i r u s v ar . v a c ­ c i n . i m b u t i paene h o r i z o n t a l i a t q u e a d e o a p t a , lit ne g u t ­ t u l a q u i d e m f a n g v i n i s e x f i i l l e t , l evi s et fufpenfae m a n u s a r t e , i n t e r c u t i c u l a m er c u t e m i m m i s f i o n e , e j u s d e m p e r d u o 1. t r i a m i n u t a f e c u n d a r i a , v i r u s a b f o r p t i o n i s c a usf a, p e r m a n f i o n e a t q u e c u m e x t r a & i f e r r i u t r i u ^ q u e faciei ad i n f l a t a m p l a g a m f r i £ t i o n e , p e r a d t a ) , f u b je c t o p r o c l i v i t a t e n e c e s f a r i a p r æ d i t o m a t e r i e m i n f e v e r a m v a r i o l a r u m v a c c i ­ n a r u m , p r a e t e r i e r u n t p l e r u m q u e q u i n q u e d i e s , i n t e r d u m l o n g i u s t e m p o r i s f p a t i u m , a n t e q u a m p r o d i d i t q u i d q u a m (fi d i l a c e r a t i o n e m e p i d e r m i d i s in p u n c t o i n f i t i o n i s , in q u i b u s d a m t a m e n , h o r i s p o f t i n f i t i o n e m a l i q u o t p r a c t e r - l a p f i s , a c i e m o c u l o r u m paene f a l l e n t e m , e x c e p e r i s ) c o m ­ m u n i c a t i o n e m v n u s fuisfe f a &a m. J a m v e r o r u b e C e r e ccepit p u n f t u m i n f i t i o n i s , t u m e r e , e t d i g i t u s , l e n i d u d t u t e n t a n s , d u r i t i e m in c u r e f e n t i r e p ot u i t . In f u m m i t a t e r u ­ b e d i n i s vel e o i pfo l o c o , q u o e p i d e r m i s ex i n f t r u m e n t o i n f i t i o n i s d i s f e £ t a f u i t , f o r m a b a t u r a v i : t o ad v m : u m d i e m p u f t u l a , q uae , q u u m m e d i u m ejus ve l locus c i c a t r i c i s , a b i n f i t i o n e p r o f e £ t æ n o n i m p l e r i p o t e f t et ci ca t r i x a d e o c u t i a d h a e r e t , u t e x f e r o a d f i u e n t e e x t o l l i n e q u e a t , v u l g o d e

pre-p r e h e n d i t u r c e n t r o d c pre-p r e s f o , ut r<e£lius a pre-p pre-p e l i e r u r v e f ic u l a a r ul r i s , q u æ p u r . & u m i n f m o n i s i. e. i p f u m c e n t r u m pe* r i p h e r i æ e l e v a t i o n s a mb i t . Q u æ p u f t u l a , p r i m o i n t u i t u h a b e n s I p e c i e m p h ! y £ f æ r i æ , e r at t a m e n , a c c u r a t i u s e x a m i ­ n a t a l o n g e alius i ndolis. O r i g o p h l y & æ n æ eft p e r f e c t a e p i d e r m i d i s a tela ce ll ul ofa p e r l i q u o r e m f e r o f u m e t n o a c l a r u m f e j u n & i o , e p i d e r m i d e m e l e v a n t e m , q u i q u e p e r a p e r ­ t u r a m q u a m l i b e t e x toro e x h a u r i r i po tef t; h u j u s m o d i i n d o ­ l i s , ex . gr. eft p uf t ul a e x c a l o r e p a u l l o i n te n f t o r i p r o f e £ l a , u t a d f p e i T i o n e f e r v i d æ a q u a e , ta£tu m e t a l l o r u m c a n d e n t i u m , e t fic p o r r o ; pu f t u la a u t e m v a c c i n a t i o n i s n o n u n a m c o n - f t i t u i t c a v i t a t e m , fed in p l u r e s p a r v a s cellulas eft d i v i f a , q u a r u m d i s f e p i m e n t a c e ll u l a r i a , d i l i g e n t i u s o b f e r v a t a , i a f u p e r f i c i e p u f t u l æ c e r n u n t u r , ct fi acu 1. a p i c e l anceolae p a r t i c u l a m a p e r u e r i s , e x h a u r i t u r t a n t u m illa c e l l u l a , c uj us p a r i e s eft p e r f o s f u s , c e t e r æ q u e p e r m a n e n t arque diftentae. F l u i d u m , in p uf t u l a v a c c i n a t i o n i s c o n t e n t u m , p e l l u c i d u m e f t , n ul lo c o l o r e , pl us m i n u s t e n u s , g l u t i n o f u m ficur a q u a i n q u a f uit g u m m i f o l u t u m , er a q u o f o e v a p o r a t o f i r m i ­ t a t e m g u m m i n a n c i s c i t u r . S ub f o r m a t i o n e p u f t u l æ h u j u s , o b f e r v a b a n t u r in i n f a n t i b u s n o n n u l l i s l e n i o r e s m o t u s f e ­ b r i l e s , vel c r e b r i u s v i v a c i t a s i n f b l i t a , in a l i i s , p r æ f e r t i r A o b e f i s et fluidi h a b i t u s d o l o r in axillis. Q u o f p a t i o p r æ - t e r l a p f o , n u l la v u l g o p r i u s e x f t i t i r m u t a t i o in f u n & o n i b u s c o r p o r i s , q u a m a r e ol a ci rca p u l l u l a m a p p a r u i t , q u o d v u l ­ g o ac ci di t a b v i i r : o ad x r m u m d i e m (ii p uf tu la v : t o a u t v i . r o d i e e s f e t f o r m a t a ) , alias f e r i u s , t u m q u e l e v i o r r u r - fus f e b r i s i n t e r d u m accesfit 12). N e c æ q u e l a t e , n e c c i t o B æ q u e

i ^ ) C o p i o fio i e m , quem in hoc ftadio apud laborantes p ro ru m p e­ re obfervarunt Celebb. B a l l h o r n e t S t r o m e v e r ( Ueber die K u h - ' pocken. Rin Be> icht an fein e M itb ü rg e r vom Hofm edikus Dr. B o d c h -h o l t z . S c h w e r i n , 1801. pagg. 2 7 , 2 8 - 6 3 ) arque M edici K ilonienfes ( U n terrich t über die K uhblattern und ih re Jchützende K r a f t gegen die

æ q i u e x t e n d e b a t u r ar eol a. E x t r a h a n c i n t e r d u m Fuir alia a r e o l a , c u m p r i o r i c o n c e n t r i c a , f e d l ar i or et d i l u t i o r i r u ­ b o r e , i n t e r d u m v e r o m a j o r e m b r a c h i i p a r r e m r u b o r o c ­ c u p a v i t . U b i a r e o l a e r a t c o l o r e r u b r i o r e , cu t i s q u o q u e e r a t t u m i d a m a g i s e t t e n f a . U t f l u id um ve f ic ul æ p e r d i d i t p e l l u c i d i t a t e m , fic o m n e iftud f e n l i m abi it et a c e n t r o in- c e p i r a r e f a c e r e , d o n e c in c r u f l a m f u f c a m et l ae ve m, c u t i a d h d e r e n t e m e t i n t e r d i e s x v . - ru m e t x x v : t u m

1

f i fcil. v a r i o l æ n o n d i s c e r p t a e f u i s f e n t , e x q u o ulcus d i u ­ t u r n i u s facile o r i e b a t u r , illa f o ’u t a m , t r a n s f o r m a t e fuisfet vef icula. C i c a r r i x i n d e c o n t r a & a e x m a g n i t u d i n e var iola* r u m e a r u m q u e f u p p u r a n d i d i u t u r n i t a t e p e n d e b a t 13). V u l ­ g o

M enjclinnblattern. A u f auerhôchflen B e j enl bekannt g e n u in e von d er medicinifchen Facultdt in Kiel, 1803. pagg. 14, 20 , fudorem non [ulla mihi videndi copia fuit.

13) Q uum nobis m odo animus fuit decurfum variolarura vacci­ n a r u m , qualem ho c te m p o re e t loco obfervavim us, ingenue referre, om ni fuperfedemus com paratione cum iis, quæ de hac re fcripta refl q u eru n t Clarisfimi Viri M u n k a f R o s e n s c h ô l d , R o u c h k o l t z e t

alii, quorum o b fe rv a ti o n e s , alio folo f a f t a s , fi a noftris haud parum d ifferrent, accuratisfimas nihilominus esfe posfe libenter co n c ed e m u s, relationem vero Cei. T h o m æ C h r i s t i e de vaccinatione in infula C e y ­ lon (vid e not. 3 fupra) ob m ajorem diverfltatem cæ li, quæ a medicis c o g n o f c a tu r , dignam esfe cum autum am us e t favore Cel. P r æ s i d i s ,

cui, P r æ c e p t o r i æftumatisfim o, cete rum quoque innumera debeo, il­ lam ad manus hæ c fcribentes h a b e m u s , ex e a , comparationis in ter va­ riolas vaccinas adeo disfitarum regio num inftituendæ g n t i a n o n ­ nulla afferre ju v a t : ” A bove t w o thoufand fiibjefts, of all ages and de- fcriptions, have been inoculated w ith c o w pox in the dlftnft o f Co- Jumbo duiing laff m onth ; a n d --- th e number o f perfons in ocula­ ted th ro u g h o u t C e y l o n , during O f t o b e r , has not been Iefs than th r e e thousand five hundred. In all th e fe , the difeafe has preferved its ori­ ginal mild n a t u re , and in no cafe have any bad confequences, or even dangerous fy m p to m s , been occafioned b y th e inoculation. In all ca­ fes in w hich the inoculation f u c c e e d s , flight inflammation aid elev a­ tion o-f the fltin are p e rc ep tib le, on th e 2 :d , 3 : d , 4Jth or f : t h d a y :

g o n o n p l u r e s p r o v e n e r e v e f i c u l æ v a r i o l a r u m v a c c i n a r u m , q u a m p î a g æ i nf i tio ni s f u e r u n r et in r r e c e f i m o c i r c i t e r q u o ­ q u e oitcE funr pu f t u l æ aliis l o t i s , p o t i s f i m u m v e r o j u xt a l o c u m i n f i n o n i s , q u æ p r i m a f r o n t e j u d i c a r e n t u r v a r i o l æ v a c c i n æ , a t t e n t i u s v e r o e x a m i n a t a e po r i u s v a r i o l i s n a t u r a ­ l i b u s i q u o d ad f a c i e m , n o n d e c u r f u m ) , e r a n t fimiles. E j u s m o d i p u l l u l a s e x t r a o r d i n a r i a s a l i aq ue e x a n t h e m a t a in aliis q u o q u e S v e c i æ p r o v i n c i i s o b f e r v a t a f u is fe , n o n l a­ t e t 14). E x p l i c a t i o , q u a m d e d i t C e l e b . D r . H . C h r . K e - v e n t e r. 15), e r u p t i o n i s m i l i a r i s , in i n f a n t i b u s l a £ l e n t i b u s , v a r i o i i s v a c c i n i s a f f e & i s , a fe o b f e r v a t æ , d e hi s q u o q u e v a l e r e f o r f a n q u e a t . Q u a n d o ca f us e j u s m o d i , ac i b i d e m p a g g . 8 e t 95 e n u m e r a t i , e x a n t h e m a t u m , e x t r a l o c a infi-B 2

tio-and about th e 6 . t h , a veficle is in general diftin&ly formed. T h i s ve- ficle, of a cellular ftru f r u re , depresfed in th e c e n t r e , and containing pellucid l y m p h , continues to increafe till ab out the 4:th d a y , w h e n th e m a tte r begins to o o z e o u t , and th e areola to f o rm ; or w h a t I think m o r e descriptive in a native fubjeét, a circular inflammation n o t unlike a com m on boil, the elevation and hardnefs o f w h ic h can be plainly felt to extend for half an inch or m o re round th e veficle. In E u ro p e a n fubjefts , this asfumes the appearance o f a beautiful fcarlet a r e o l a , and is th e principal diftingvishing chara&eriftic o f th e diseafe, w i t h o u t w h ic h th e inoculation cannot be confidered as eflV&ive. A b o u t t h e i2 jth d a y , th is circular inflammation g radually fubfides, and the w h o l e o f th e matre" having oozed from th e veficle, n o w forms a Thin­ n in g fcab o f a b ro w n co lo u r, w h ich in a few d ays drops off, and fometim»*s leaves a fuperficial fore behind it. T h e fize o f th e puftule is various in different fu b jefts, but th e circum ference o f th e veficle in gen e ral exceeds f o m e w h a t th a t o f a la rge pea. Pain in axilla, th o u g h n o t a l w a y s p r e f e n t, is a v e r y confiant attendant o f th e diseafe, and generally com es on about th e 5:th . and lafts to t h e io :t h day. So- «ne d e g re e o f fever is alfo in mofi infiances prefent for a d ay or t w o , and g enerally accedes about th e 4 : t h , 71th, or 8:th d a y . ” L. c, N:o y . p. 432.

14) Låkaren och N a tu rfo r/k a ren , X V :de B. p a g g . 1 3 , 127. J5) Ibid. p, 23 8 .

r i o n i s , varioHs- va c ci n is p e r f e £ l e f i m i l i u m , o c c u r r u n t , in- f i n i u n t u r e x p e r i m e n t a i nl ir io ni s e x hi*ce v I k u l i s , u nde e l uc e ar 3n illa arque ac i pfæ v a r i o l æ vaccinae in pu n d t o i nl i r i o ni s v e r a s p r o c r e e n t v a r i o l a s v a c c i n a s , ac d e i n d e vel p e r v a c c i n a r i o n e m faepius r e p e t i t a m , vel l i b e r o ac ces fu c o n t a g i o n i v a r i o l a r u m d a t o , o b f e r v e r u r an e a n d e m h a ­ b e a n t v i m t u e n d i c o n r r a v ar i o l a s n a t u r a l e s , infintias et va c­ c i n a s , ac v e r æ v a r i o l æ v a c c i n æ ; n o n d u m feil, lufficiunt e x p e r i m e n t a u t h æ c r e s ft ab i li at u r 16). N u l l i fecuti funt

m o r

-16) De variolis vaccinis extra p u n ftu ræ loca Cel. C h r i s t i e hæc h a b e t: " A l t h o u g h the occurrence o f any pullule, except on the in­ oculate d p a rts, is an extrem ely rare occurrence in the true vaccine dise afe, and is , I believe, Hill doubted by Dr. J e n n e r , „yet w e have on Ceylon certainly feen three or four inftances* w here one or m o re p o llu tes, bearing all the charafreriftics of the vaccine * have ap­ peared on parts of the body rfiftant from the feat o f inoculation, and w h i c h I cannot conceive w e re occafioned either by an accidental prick o f th e la n ce t, o r from a fecondary inoculation, by means of the Pa­ tie n t fcratching the puftule, and afterw ards another part o f his body* and a t a time w h en no virus w as formed in the inoculated pullule. T h i s is molt ftrongly exemplified in the cafe o f a b o y * n o w under th e care o f Mr. O r r , in w h o m a diftintt* wellmarked vaccine pullule appeared* on the back part o f the th ig h , on the fourth day after in­ oculation in both arms. T h e inoculated parts fhew ed the ufual ap­ pearance of incipient pullules on the third day, and on the follow ing th a t on the thigh appeared, fince which time the tree pullules have run th e ir courfe regularly. Mr. C a r n i e formerly inoculated at Jaffna- patnam , w i t h matter taken from a fecondary pullule on the wriH, and w i t h it produced the true vaccine diseafe.” — — — " I have never feen an y general eruption w hich 1 could w ith reafon attribute to th e vaccine inoculation. _{Patients under vaccine inoculation have ©ccafip«} r a l l y f h e w n me flight eruptions o f pimples* or prickly heat, flt the appearance of w hich th e y w e r e alarm ed, but thefe have fpon di-ed a w a y , qnd feemed to trie be o nly cafual eruptions, which are fo com ­ m on at all times in this country* and mull necesfarily be more fre­ q u e n t , w h e n the patient labours under a n y febrile afieftion.” L. c. N:o> V - pag. 434- feqq. Cfr. B o u c i i h o l t z I. e . p. 29, feqq. et

= = = = = i j m o r b i f e c u n d a r i i 17). I n t e r d u m vifa eft mi li ar i s q u a e d a m , vel e t i a m ur aliis acci di t 18) e r y f i p c l a c e a e r u p t i o , f p o n t e n e c ullius o p e r a i n t e r v e n i e t re p l e r u m q u e ab iens . S c a b i e s , p r o p t e r m u n d i t i e m n e g k d a m i n fa n t e s p l e b i s n i m i s ur<- g e n s , in n o n n u l l i s p e n i t u s d e f i i r , in p l e r i s q u e ur a n t e a p e r r e x i t , i n t e r d u m , ex a lu s f o r f a n caufis q u a m p a r v a illa f u b d e c u r f u v a r i o l a r u m v a c c i n a r u m c o r p o r i s i r r i t a t i o n e , a d t e m p u s a c c r e vi t. Q u o s u r g e n t i o r i n V af e ra t f c a b i c s , v e l n o n o m n i n o afficere p o t u i t v a c c i n a r i o , vel p r o d i e r u n t p u f l u l æ , f o r m a a t q u e d e c u r f u v e r i s v ar i o l i s v ac c i n i s a d e o d i s ü m i l e s , ut p r o f p ur ii s eas h a b e r e m , ar que d u m in iltis f u b j e & i s v e r æ v a r i o l æ vaccinae p r o v e n e r i n t , n o n r a r o bis t e r v e i n f i t i o n e m r e p e t e r e fuit necesfe. Si d e c u r f u s i d e m , q u e m d i x i , ( pa ull o o ci us f e r i u s v e a b f o l u t u s , m a j o r i m i n o r i v e f e b r i , r u b e d i n e et c i r c u m infi- t i o n i s l o c u m t u m o r e p r o v ar i i s v a r i a n t e f u b j e d i s ) f u i s f e t , c e n f u i e s fe v e r a s fic d t d a s v a r io l as v a c c i n a s , a va r iol i s n a ­ t u r a l i b u s fuo g e n e r e v a r i o l a r u m a l i q u a n d o afF d u m c o n - f e r v a n t e s , in q u e m i nfitio v a r i o l a r u m n a t u r a l i u m aut v a c ­ c i n a r u m nihil o l i m u n q u a m efficere p o t e r i t , q u a m q u o d o m n i s alia Tub v ar i i s c o n d i t i o n i b u s i i n t a t i o loci faciat 19)* D e

-ßtch m tg en u n d Beobachtungen Uber na tü rlich e, zu fä llig e und g eim p fte Kuhpocken von Dr. Ge o r g He i n r i c h Ma s i u s. Leipzig 1803. p agg. 6 3 73. M ed . Chir Z e it. 7:ter Ergänzungsband. p. 209.

17) N ec u l l o s tam l e v e m , quam variolæ vaccinæ funt, corporis affcftum fêcnturos (sfe exfpe&averit » qui. qnæ Cel. D . K ü s t e r ad-

verf us M u r c u m H e r z (v i d e : N eues ffo u r n a l d er praïïifchen A r z n e y - k m d e und I f'u n d a r z n e y k u n ß , herausgegeben von C. W. ü h f e l a n d.

7:fer B. 3 St. Berlin 1802. p l i o , feqq.) attu lit, probe contenderit argumenta.

18) L akaren och N a tu r f o r f k i r en. X V :de B. p. 127.

19) Piget me tunc temporis ignorasfe experim entum , quod po-ex P ræ le f t publicis Cel P r æ s i d i s et libro Celebb. Viror. J. B r y ­ c e et F, G, F r i e s e (vide not. 6 fupra) didici esfe c e rtisfim u m , quo

D e c i i r f u v e r o a d e o disfimili e x i f l e n t e , ur j-’ m flie poft i n f i r i o n e m f e c u n d o l ocus inf i ri oni s i r f l a m m a r i i c c p i s fe t ct à m i n o ad i v : r u i n d i e m v e f u u l a l a£ l c o 1 l u t e o l o c o l o r e p r o d i i s f e t , n e c f ic, ut quae n u p e r eft d e f c r i p r a , r o t u n d a , n e c in m e d i o i m p r e s f l o n e f u p r a d i £ l a , n e c in p l u r e s cel­ l u l a s , c l a r o l y m p h a t i c o h u m o r e i m p l e r e s , d iv if a , f e d pus q u o d d a m t e n u i u s e x f l i l l s n s ar que V t r u m fiflens u l c u s c u ­ l u m , nec h a l o n e e r y l i p d a t o f o - p h l e g m o n o i d e a c i r c u m d a t a , fi d e n i q u e , c u m iniitio e x r n a t e r i a i n d e f u mt a p . r a & i flr, u i c u s e j u s d e m t a n t u m i n d o l i s o r t u m e s f e t , f p u r i a s , quas a p p e l l a m u s , c e n f u i eas esfe v a r i o l a s , n o n m a g i s quanr ul­ c u s fcabLofum a l i a m q u e p u f t u l a m c o n t r a v a r i o l a s n a t u r a l e s aut

de ju fta , f. co n ftitu tio n a li, ut ajunt Medici, a variolis vaccinis :>ftV6lio- n e corporis dijudicari posfir; ad finem fciiicet diei quinti vel in initio fexti a vaccinatione f. cum ex loci et te m peftjtis ratione (fi quid mu­ t e n t) obfervatum e f t , quo areola maxime appare ,t t e m p o r e , ante id ipfum circiter triginta fex ad quadraginta o6to horas nova inftituatur in- f itio , quæ, fi priorem probe fenferit c o rp u s , f. quod id* m e ft. fi totum c o rp u s a priori virus vaccini infitione, etiamfi p r externa et fenfuum perceptioni aperta indicia, id non p ro d itu r. r~ vera afiVftum fu e r it, ad e o feftinat, u t , biduo vix t r a n s a f t o , puftulæ et a r e o læ , ex hac fe­ cunda vaccinatione exortae, pari cum prioribus pasfu ambulant E x p lo ­ rato ria m iftam vac c in a tio n em , fi ferius jufto inftiruifnr, nifi p rior fru- ftranea fuisfet, effe&u omnino carere et propius p r io re m , antequam illa co rp u s movere incepit, fi p era g itu r, p raecellentem , quam d ix im u s , de- curfus feftinationem defiderare , in aperto eft. ” It w as firft rem arked b y th e late Dr. W o o d w i l l e , that if a perfon is inoculated t o - d a y w i t h f m a l l - p o x , and th ree or four days afterwards again inoculated w i t h th e fame morbid po ifo n , both th e inoculated places will arrive at th e i r heigth at th e fame time. T h is is ftriftly t r u e , and the o n l y dif­ fere n c e b etw e en th e t w o infertions will be th a t th e laft rarely equals in fiz e . th ough it arrives at the fame ftag e , o f m a tu rity with the firft. T h e fame has alfo been obferved o f C o w - p o x ; and this is n o w fo w e l l k n o w n , th a t th e fécond infection has been propofed as a te ft o f p e r f e t t vaccination.” A p o p u la r Vi tw o f V accine In o cu la tio n , &c. By

a u t i n f i t i o n e m v a r i o l a r u m v a c c i n a f u m n o n f r u f t r a n e u m , h o m i n u m g e n u s c o n f e r v a n r e s . A n u n q u a m m a t e r ia ex (pu- r i i s v a r i o l i s v a c c a r u m d e i u m t a , hei c f ue rir ad h ib it a et p r o p a g a t a i d e o q u e in h o m i n i b u s S v e c i æ o b f e r v a t æ fint fpu- r . æ var iola? v a c c i n a ? , n o n d i j u d i c a r e e g o Cum po t i s , f e d e a s , quae v u l g o h o d i e fic a p p e l l a n t u r e o d e m q u e m o d o fe h a b e n t ac i l l æ , q u æ (jam d e f e r i p r æ ) et in Svec ia 20) et a p u d e x t e r o s 213 fpuriae d i c u n t u r , a v e r i s q u o q u e v a r i o ­ las v a c c i n i s o r i r i p o s f e , m a r e r i a fcil. infirionis, n o n t e m p o ­ r e o p p o r t u n o , n cc m o d o d e b i t o f u m t a vel infitione altius j u ft o i m p r e s f a , ficque n i m i a m f t i m u l a t i o n e m ex c ita nt e , ipfl m i h i licuit v i d e r e . Q u o d in aliis o c c a f i c n i b u s , u t q u u m i n f i t i o in il lo, qui v a r i o l a r u m m o r b u m a n tea pasfus f i t , v e l f a l t e m in p r æ f e n t i n u l l a m a d e a s habe ar p r o c l i v i t a t e m , t e n t a t u r , v a c c i n a t i o e x g e n u i n a m a t e r i a v a r i o l a r u m v a c c i ­ n a r u m , f u m m a a n i m i a t t e n t i o n e et f e c u n d u m re g u la s a r ­ tis c o n f e £ t a , q u i d q u a m efficiat, q u o d , e x d e f e r i p t i o n e j a m d a t a v a r i o l a r u m v a c c i n a r u m g e n u i n a r u m et f p u r i a r u m , n e u t r i u s dici q u e a r g e n e r i s , u t , c u m di e ah infitione n : d o r u b o r c u m p r u r i t u in p u n f t o i nl ir ion is f e n tirur, i n t e r d u m q u o q u e d o l o r in a x i l l i s , r u b o r p e r u n u m a l t e r u m v e d i e m a u g e f e i t , er p o f t fine p ul l ul a et f u p p u r a t i o n e abit , aut c u m f t i m u l a t i o l e v i s , f ub i n fi t i o ne fe nl it a er m o x in loco i p fo r u b e d i n e m e x c i t a n s , n u l l o d o l o r e e v a n e f e i r , ubi infitio d i ­ c i t u r n o n p r o c e s f i s f e , m e q u o q u e e a d e m e x p e r t u m do- c u i r , q u o d , q u a m v i s n o n n o v u m et i n a u d i t u m t a m e n p l u ­ r i e s i n c u l c e t u r v a c c i n a t o r i b u s i m p e r i t i s , i n d e , q u o d p o ft u n u m a l t e r u m v e e x p e r i m e n t u m d iv er f is t e m p o r i b u s infi­ t i o n e v a r i o l a r u m v a c c i n a r u m c o n f v e t a a n i m i a t t e n t i o n e p e r -a £ t u m ,

2 0 ) L å la ren och N ittu r fo r (karen. X Vrde B. p. 23

-2 1 ) Ban-iliuch d er Pathologie. V o n Dr. A d o l p h H e n k e , a l t e r

a £ f u m , v e l l evi s vel nulla a p p a r u e r i t c f f r a c i a , n o n p r o c e r t o esfe f t a t u e n d u m , f u b j t & u n q u o d d a m a n t ea v riolis fuisfe a f f . £ t u m , t rcia e n i m et q u a r t a v ice fuccesfi t in- fitio 2 2 )

lix h a c et aliis caufi s, fub v a c c i n a t i o n i s o p re m i h i o c c u r r e n t i b u s , p e r u r i l e c r e d o f o r e , f i , q u a m d i u p r i m a h u j us r ei r u d i m e n t a p e r I nf ti tut a e m e n d a t i o r a v u l g i c a p t u i n o n d u m f u n t c o m m u n i c a t a , v a c c i n a t o r m a t r e m q u a m q u e , c o g n a t u m , v e r b o , c u i c u n q u e fit m a n d a t u s i nf an s a f f u i e n d u s , a u t et iam illum i p f u m , fi p r o «jetate p e r c i p e r e p os fi t didta e t ea f e q u i , pauc is a d m o n e a t : «:o. U t , li i n fi t io h a c v i c e n o n p r o c e s f e r i t , q u u m v i ­ r u s v a c c i n o i m b u t u s v e l q ui e u m f u n t c o m i t a t i , f u pe r va * c a n e u m c e n f e r e n t i t e r u m c o r a m v a c c i r. a ro re v e n i r e , r u r - fus v a c c i n a t i o n i f r uf t r a fubj £ t u s , p r o x i m a ? m o x fe fi 11 ac j n f i n o n i 2 3 ), aut p r o r e nat a l o n g i o r i f pa ti o p r a e t e r l a p f o , d o n e c p e r e x p e r i m e n t a i terata fa£tus fit m a x i m e q u a m fie­ r i p o t e l t c e r t u s , fe a n t e a , q u a m q u a m o c c u l t e var iol as est e

p a s f u m , vel f e b r i m v a r i o l o f a m , e a d e m f o r f an e f f i ci e n ­ t e m 2 4 ) , vel c o r p u s fuurn a d e o es f e c o m p a r a t u m ut luei va*

22) Ita quoque cum variolis naturalibus (Vfe habuisfe n o v i m u s ex

l i b ro citato (Vide not. 5 fupra/ Nobilisf. ü a v . S c h u l t z ( v o n S g h u l - z e n h e i m . n. t.) p. 89- et B eråttelfer inläm nade till K ong I. CoUeg. M ed ic u m , &c. Stockh. 1765. p. '253.

2 3 ) Hujus docum entum vi de s i n : L ä ka ren och N a tu r fo r fk a r en, X V .d e B. p. 75.

2 4 ) D a v i d S c h u l t z v o n S c h u l z e n h e i m 1. c. p a g e . 8 5 »

8 7 - — B erå ttelfer inlämnade till K ongl Colleg. M odicum, &c\ Stockh.

1 7 6 5 . p. 2 9 . — In V a rio la ru m m jitionem O b ftr v a tw n e s , quas Prcefi- de J o h . G u s t . A c r e l pro Gradu Do&oris pubi, fubjicit examini Ni­

c o l . A l m r o t h . Up f ai i æ 1788 P 9* — B ericht der Commis (io n, welche von der Clasfe der mathem atifchen u n d phyfekalifclun IVisfen- fc h a fte n des N a tional - I n ß itu ts z u P a r is z u r U nterfuchung der Me~ thode die K inderblattern durch Im p ju n g der Kuhpocken z u ve rh ü te n , ern a n n t w a r . V ide: M ed. Chir, Z e it. 8:ter Ergânzungsb. N. 229. p. 4 2 1

-v a r i o l a r u m n u n q u a m fir o b n o x i u m 2 5 ) . G r a v i o r e m m ö r - b u m e x o n t h e m a t i c u m j a m d u m p e r g e n t e m , aut n u p e r fini* t u r n i d e m ef fi cer e i n c o r p u s ac v a r i o l a s , u t in p o f t e r u m a b illis fit t u t u m , n o n c o n f i d i m u s ; n e î e p r a q u i d e m , t a n ­ t o p e r e c u t i m c o m m u t a n s a d v e r f u s v a r i o l a s f e r v a r e v a l e t 26), 2 î o . A d m o n e n d u m , v a c c i n a s n o n p l u s q u a m v a r i o l a s n a ­ t u r a l e s a d v e r f u s v a r i c e l l a s ( va r i ol as f p u r i a s , a n o m a l a s , d i e f a l f c h e n P o c k e n , V a s f e r p o t k e n , L a p e t i t e v e r ö l e v o l a n t e , C h i c k e n P o x ) a l i o s q u e m o r b o s e x a n t h e m a t i c o s t ue r i . Sic, fi v a r i o l i s v a c ci n is d e f u n f t u s n o n d u m l a b o r a v e r i t v a r i c e l -C lis, 2 5 ) D a v . S c h u l t z v o n S c h u l z e n h e i m 1. c. pagg. 8 8 , 89»

t i o . — A d o l p h H e n k e l. c. p. 5 7 . — B erich t d e r Commis/ton, & e .

p. 4 2 3 . — N y t Bibliotkek f o r P h y jik , M edicin og Oeconomie. U d g iv e t a f C, P. R a F N . Kjöbenhavn , 1801. 1 B. 4 Heft. p, 4 4 5 .

2 6 ) ” In a form e r le tte r I had occafion t o mention for th e infor­ m ation o f y o u r Medical r e a d e r s , th e vaccine diseafe having been co m ­ m u n ic a ted to a b->y aflfe&ed w ith leprofy ; and from a m elancholy in- ftance w h i c h has fince occurred, it is certain t h a t perfons affetted w ith th a t diseafe , in th e moft malignant f o r m , a re n o t ex em p t from th e co n tag io n o f fmallpox.”

” Clar3 de Silva, a w o m a n , aged about 50 y e a r s , w h o had been confined in t h e Lepers Hofpital fince May 1 7 7 5 , w ith leprofy in th e w o r f t form , having been expofed to variolous c o n t a g i o n , fickened about lift o f A u g u ft , 1 8 0 6 , and died on the n : t h o f th a t m onth w ith c o n ­ fluent fm allp ox. On th e appearance o f fmallpox in th e neig h b o u rh o o d o f th e L e p e rs Hofpital in May 1806, vaccination w a s prattifed am ongft th e p atients o f th a t Inftitution, but th is old w o m a n declared f h e had had t h e fmallpox w h e n a child and refuted to be inoculated. T h e f a i t m a y be u t e f u l , b y f h ew in g th a t no diseafe o f th e fk in , h o w e ­ ver virulent gives p erfefr fecurity againft fmallpox ; and th a t in t h e event o f an epidemic c o n t a g io n ; no confederation o f th a t nature o u g h t t o p re v e n t us from a ttem pting to fhield th e confiitution againft its iu, f l u e n c e , by vaccination,” T h o m , C h r i s t i e 1, c. N:o V III. p. 209,

l i s , fieri p o t e f t , u t o c i u s f e r i u s illis l a b o r e t , i d e o eas a va» r iolis n a t u r a l i b u s d i g n o f c e r e d i f c a t , q u o e r r o r eas p r o v a - r i o l is v e r i s h a b e n d i e v i t e t u r et ne v a c ci n at i o n i o b j i c i a t u r, ei n o n esfe v i m i l l a m , t a n t o p e r e j i & a t a m , c o n t r a v a r i o ­ las n a t u r a l e s f e r v a n t e m . C u m v a r i o l æ n a t u r a l e s es f en r v u l g a r e s , qui sq ue f e r e illas v i d e r a t a d e o q u e v a r i c e l l a s , fi u n q u a m o c c u r r e r a n t , d i g n o f c e r e p o t e r a r . Quae d i f f e r e n t i a p l e r u m q u e turn fuir facilis c o g n i t u , a d n o t a b a n t u r f o l u m m o d o quae in i l l i s e r a n t d i s f i m i l i a ; h o d i e y e r o u bi v a r i o l æ n a t u r a l e s (quo d n o f i r o aevo g r a t u l e m u r ) t a m rarae fune v i f u , n ec es fe eft u t , q u o r e s fiat e v i d e n t i o r , paene u t r i u s q u e g e n e r i s d e c u r l u s p r o ­ p o n a t u r . _{H a b e s h ei c m o d u m B. L . q u o p e r f p i c u a m v u l ­} g o r e d d e r e f tudui h a n c d i f f e r e n t i a m . U t e r q w e m o r b u s fe­ b r i , d o l o r e c a p i t i s , in v o m i t u m p r o p e n l i t a t e , c o n v u l f i o n e a r t u u m , cetr. i n c i p i t j fed fi p o f t l itam v a l e t u d i n e m v n r io - læ p r i m o d i e h ic illic in c o r p o r e p u l l u l e n t er fic d i e b u s a l i q u o t p e r g a n t , ita u t , p uf iul a u na a r e f e e n t e aüa p r o r u m ­ p a t , u n a a b e u n t e a lt e r a n o n d u m a d m a t u r i t a t e m fit p e r ­ v e n t a , u n a c u m d e s q u a m a t i o n e exili a b e a t , altera in c r u - f t a m f u b i t o t r a n s m u t e t u r , nonn ul l ae q u o q u e f u p p u r e n t u r ci- c a t r i c e m q u e f a c i a n t , er fic p o r r o , f e m p e r fere ita, ut va- r i o l a r u m quaeque f e n f i m f u u m d e c u r f u m h. e. fi adi um e r u ­ p t i o n i s , f u p p u r a t i o n i s et ex f ic c at i on i s f p a t i o t r i u m d i e r u m c o n f e c e r i t , c o n f i a t esfe eas g e n e r i s v a r i c e l l a r u m , verae e n i m v a r i o l æ t e r t i o d e m u m d i e p o f t i n i ti u m febri s fe o f f e n ­ d u n t , p r i m u m f e m p e r in f a c i e , d e i n m a n i b u s , t r u n c o , t a n d e m in e x t r e m i t a t i b u s i n f e r i o r i b u s , c u m t ant a p r o g r e s - fus a e q ui ta t e , u t f e re f e m p e r , fi m a g n a vis fit v a r i o l a r u m , d i e p o f t e r u p t i o n e m q u i n t o t u m o r ce d em at o fu s c e r n a t u r in o r e , p o ft in b r a c h i i s e t t r u n c o , p o f t r e m u m in e x t r e m i ­ t a t i b u s i n f e r i o r i b u s , e o d e m q u e o r d i n e e x f i c c e n t u r v a r i o l æ et in c r uf t as f o r m e n t u r , q u o d v u l g o fit di e ab i ni ti o m o r ­ bi f e p t i m o . Sic pr a ec i pu e e x d u p l i c i i n d i c i o d i f t i n g u u n t u r

ve-v e r s e ve-variol a? a fpuriis : 1:0 q u o d cerro o r d i n e faciem p r i ­ m u m , t u m e x t r e m i t a t e s f u p e r i o r e s et t r u n c u m , p o r t r e m u m f e m o r a a t q u e c r u r a i n v a d u n t . 2 : 0 Q u o d quaeque v ar i o ia- r u m f e o r l i m fpe£tara d i u t u r n i o r e m h a b e t decui fum, neces- f a r i u m fcil. eft illud o b f e r v a t u , n a m u t variceliæ, nullo c o r ­ p o r i s p a r t i u m quafi h a b i t o r e ( p e £ t u , hic illic e x f u r g u n t , f i er i q u i d e m p ot cf f , ut a b o r t u prim ae v ar ic el lar u m ad iinem u l t i m a e , t a n t u m t e m p o r i s e v a o a t , q u a n t u m decurfui va rio - . l a r u m v e r a r u m fufficcrer, pr a e fe rt im q u u m i n t e r d u m puftu- l æ v a i i c e l l a r u m d u r e n t plus fo li to dies c ir c ite r d u o 27) h u m o r e f u o d i f t i n c l æ , vel tar di u s p r o v e n i a n t et dec urfu lint l o n g i o r i , q u o f a f t o facilius m u l t o , r e b u s o m n i b u s utrius- q u e g e n e r i s v s r i o l a r u m n o n rite p e r p e n f i s , p r o variolis h a b e r e n t u r . _{E j u s m o d i o b f e r v a t i o n e m r e p e r i m u s a Cei. As*} fesf. C. M . B l o m p e r f c r i p t a m 2 8 ) . F o r m a q u o q u e v a r i a n t v a r i c e l i æ , a d e o u t , p r æ r e r n u p e r d e f c r i p t a s p r o p r i e fic di- & a s v a r i o l a s l y m p h a t i c a s , ftnt e æ , q u a r u m p u d u l æ p l e ­ r u m q u e f u n t r o t u n d a e , n u n c m a j o r e s n u n c m i n o r e s , i m ­ pletae l y m p h a a l b i c a n t e et p e l i u c i d a , p a r v a in a c u m i n e i m p r e s l i o n e , q u u m i n t e r d u m a d e o v e r is funt fimiles ut j u d i c e s e x p e r i e n t i s f i m i p r i m o i n t u it u eas lie fere jud ic av e­ r i n t 29).

C 2 _{F t e}

--7 J _{B srå tte lje r inläm nade till Ko nul. Collegium M edicum , &c.} S to ck h 1765. p. 71.

28 ) _{BeràttelJ'er tili R ikfrns H ogloß, S ta n d e r rôrande M edicinal-} JF erkets till/lånd i liikct. Upfala 1769. p. 33,

2 9 ) _{" S e deceptum fetnel fuisfe mi hi (litteris m. Aprilis an. 1766} exaratis) expofuit eruditione non minus quam humanitate eximius, Cel.

D a v , Sc h u l z, _{dum a comite quodam vocaretur ad judicium d e va-} ric.farum penere , ab experto quodam medico pro veris habitarum, quo illuftmf. Viri liberi æ g ro tabant, ferendum. Primum cot.clave ingresfus, ubi duo ejus filii decum bebant, confeflim ex verarum iftas esfe tribu pro n u n tia v it, utpote copiofas et probe repletas. Quum vero in proxi­ m um conclave fe c o n f e rr e t, fororem ibi in l e f t o o ffe n d it, e x a n t h e m a -

2 0 =====— = = = = = 5

F i e r i q u i d e m p o s f e n e c i n c r e d i b i l e , q u a m v i s fit r a ­ r u m a u t u m o , u t v a r i o l æ n o n u n o v e f t i g i o e t p e n i t u s a d e o

i m m u t a v e r i n t c o r p o r i s h a b i t u m et p r æ f e r t i m c u t e m , u t n o n i t e r u m v a r i o l i s f u f c i p i e n d i s iit a p t u m 30) U t v e r o - f i m i l i t e r ha:c r a t i o eft v a r i o l a r u m n a t u r a l i u m 3 « ) , quae v u l ­ g o c o r p u s v e h e m e n t e r a d f i c i u n t , q u i d i m p e d i t q u i n e a d e m fit r a t i o v a r i o l a r u m v a c c i n a r u m , q u a r u m vi s in c o r p u s l e­ n i o r v a l d e eft? S e d , fi p r o b a b i l i t a t i h a u d c e n f e a m c o n ­ t r a r i u m , v a r i o l a s v a c c i n a s n o n pl us q u a m n a t u r a l e s ita fub- j e £ l u m q u o d d a m a f f e c i s f e , u t m o r b u s r e c i d i v u s n o n o m n i ­ n o e s f e t m e t u e n d u s , q u o d t a m e n , r e p e t i t i s p l u r i e s i nfi tio- n i b u s , c o m m e r c i o c u m v a c c i n a t i s d i u t u r n o , e t l i b e r o ac- c e s f u luei v a r i o l a r u m d a t o , n o n d u m e x e m p l o c e r t o e t fir­ m o , u b i v e r æ v a r i o l æ vacci nae infitae f u i s f e n t , a d f i r m a r i p o t u i t , n o n p e r f p i c i o , a n , e f to q u o q u e e j u s m o d i c a f u s , v a t e m naturae c o r d a r u m ea r e s v a l d e p e r c e l l a t , vel m o d o q u o d a m q u i d q u a m d e d i v i n a h a c Je n n e r i i n v e n t i o n e d e ­

t r a h a t .

p u re ly m p h a q u e c o m ro iftis, quafi variegata. Sub foilertiori fcrutinio in fratribus ejusdem generis exanthem ata , p er corpus difperfa invcnif. Quilib et horum infantum febrem fab eruptione leviorem fenferat, e t in fin- guiis frequens fuit ex anthem atum m a g n o r u m , quoad plurimam p rtem p u re r e p l e t o r u m , p ro v e n tu s , quæ per 8 ^ 9 dies fupra cutem fubfti- t e r u n t , fed line aliis morbi indiciis.” Vide J o a n . A n d r . M u r r a y

H ijio r . P a rio la r . & c . (in not. 5 citat.) p. 14. — The M e i, a n d Chi- r u r g . R eview . N:o X C I . Mifcellaneous. p. L X X .

3 0 ) D a v . S c h u l t z v o n S c h u l z e n h e i m 1. c. p. 104. — N eue S a m m l. aufserles. IV a h rn th m . B. 1. p. 154.

31) The L ondon M edical and S u r g ic a l S p e ïïa to r . NT:o III. 1808. p. 299. — N:o V. p. 4 4 0 . Cfr. P athologie o d er L ehre von E ffe kte n des lebendigen O rg a n ism u s von J. D. B r a n d i s . H a m b u r g , 1808. p.