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Clinical evaluation of local antibiotic treatment in smokers with chronic periodontitis in a maintenance care program

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Objectives

To evaluate if local antibiotics, 8.8 %

doxycycline gel, can improve periodontal healing in smokers in a maintenance care program.

CLINICAL EVALUATION OF LOCAL ANTIBIOTIC

TREAMENT IN SMOKERS WITH CHRONIC

PERIODONTITIS IN A MAINTENANCE CARE PROGRAM

Kerstin Stagnér

1,2

, Gunilla Bratthall

2

Dental Hygienist Education

1

, Department of Periodontology

2

,

Faculty of Odontology, Malmö University, Sweden

Conclusion

This study could not show any statistically significant clinical differences between the test - and control groups based on results of index teeth as well as all teeth. This

means that local antibiotic treatment with 8.8 % doxycycline gel (Atridox®) did not

show any additional effects to scaling. The results, however, showed significant

improvement of periodontal pockets after subgingival scaling in both test- and control groups.

Methods

In a double-blind controlled study 20 smoking patients were divided into the test group (8.8 % doxycycline gel) and the control group (placebo gel). At

baseline all subjects received full-mouth scaling followed with application of test or placebo gel in all index pockets ≥ 5 mm (PPD).

RESULTS

20 patients (N=16) Baseline, total 265 teeth, 150 teeth PPD ≥ 5 mm

Scaling/Debridement (fullmouth incl molars) Testgroup 10 (N=6)

Baseline 49 teeth PPD ≥ 5 mm

Controlgroup 10 (N=10)

Baseline 101 teeth PPD ≥ 5mm Scaling/Debridement

(fullmouth incl molars)

Doxycyklingel (Atridox®)

pockets ≥ 5 mm Placebogel pockets ≥ 5 mm Results: Testgroup 3 months PPD: -1,36 mm (p=0.0313) Results: Controlgroup 3 months PPD: -1,07 mm (p=0.0020), CAL: -0,65 mm (p=0.0200), BoP: (p=0.0078)

Results: Material total incl test- and control, 3 months

PPD: (p=0.0039), CAL: (p=0.0195), BoP: (p=0.0254), GI: (p=0,0039)

Baseline 21 pockets ≥ 5mm 3 months 11 pockets ≥ 5 mm

3 months 5 pockets ≥ 5mm Baseline 12 pockets ≥ 5mm Women 1948 Man 1947 Atridox® 44g (8,8 %) Doxycycline, Atrix Laboratories, USA.

EXPERIMENTAL DESIGN

Randomizing, test and controlgroup Study information Inform approval Indexteeth Clinical photo GI, Periotron® PPD CAL BoP PLI Scaling/ Debridement, fullmouth Doxycycline- gel/Placebo-gel Clhx 7-10 days Remove remaining gel Polishing Clinical photo GI, Periotron® PPD CAL BoP PLI Study finished Screening Baseline Visit 1 1 week Visit 2 2 weeks Visit 3 3 months Visit 4

References

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