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Pernilla Eliasson Response to mechanical loading in healing tendons Linköping 2011Pernilla Eliasson Response to mechanical loading in healing tendons Linköping 2011

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Questions Methods Evaluation Answers

I Can short daily

loading episodes improve tendon healing? Yes II Has loading different impact on early and late healing?

No

III Does unloading

influence ECM, inflammation and tendon genes during tendon healing? Yes IV Is the BMP- system regulated during tendon healing? By unloading? Yes No V Can myostatin stimulate tendon repair? Is it regulated by unloading? Yes Yes

VI How long does

the gene expression response last after loading? Gone by 24h.

Response to mechanical

Response to mechanical

loading in healing tendons

loading in healing tendons

Pernilla Eliasson

Pernilla Eliasson

Thesis at a glance:

Thesis at a glance:

Linköping University Medical Dissertations

No. 1247

Pernilla Eliasson Response to mechanical loading in healing tendons Linköping

201

1

Pernilla Eliasson Response to mechanical loading in healing tendons Linköping 2011

Linköping University Faculty of Health Sciences

Department of clinical and experimental medicine Division of Orthopaedics

(2)

Questions Methods Evaluation Answers

I Can short daily

loading episodes improve tendon healing? Yes II Has loading different impact on early and late healing?

No

III Does unloading

influence ECM, inflammation and tendon genes during tendon healing? Yes IV Is the BMP- system regulated during tendon healing? By unloading? Yes No V Can myostatin stimulate tendon repair? Is it regulated by unloading? Yes Yes

VI How long does

the gene expression response last after loading? Gone by 24h.

Response to mechanical

Response to mechanical

loading in healing tendons

loading in healing tendons

Pernilla Eliasson

Pernilla Eliasson

Thesis at a glance:

Thesis at a glance:

Linköping University Medical Dissertations

No. 1247

Pernilla Eliasson Response to mechanical loading in healing tendons Linköping

201

1

Pernilla Eliasson Response to mechanical loading in healing tendons Linköping 2011

Linköping University Faculty of Health Sciences

Department of clinical and experimental medicine Division of Orthopaedics

References

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