2016In vitro toxicity testing using human pluripotent stem cell derivatives | Gustav Holmgren

hepatocytes and cardiomyocytes, derived from human pluripotent stem cells (hPSC) as in vitro models for toxicity testing.. The first part explored the feasibility of using

Keywords: human pluripotent stem cells, gene transcription, gene regulation, DNA methylation,

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To explore putative mechanisms regulating the di fferentiation toward the hepatocyte lineage, a TF enrichment analysis was performed on dataset E-MTAB- 5367 using the identi fied sets

Our results are consistent with similar studies comparing human primary hepatocytes to hPSC-HEP generated using an earlier generation of the differentiation protocol used in the

Towards gaining better understanding of the differentiation and maturation process, we employed a standardized protocol to differentiate six hPSC lines into hepatocytes and

With their proliferative capacity and differentiation potential, human induced pluripotent stem cells (iPSCs) represent an appealing cell source for such a model system

For example one has multipotent stem cells in the brain that produce only different types of neural cells.. Since adult stem cells only produce limited types of cells they