• No results found

Regulation of IL‐6‐signaling and inflammatory response ‐role of insulin, FOXO1 and PKCδ

N/A
N/A
Info
Download
Protected

Academic year: 2021

Share "Regulation of IL‐6‐signaling and inflammatory response ‐role of insulin, FOXO1 and PKCδ"

Copied!
4
0
0

Loading.... (view fulltext now)

Download now ( 4 Page )

Full text

(1)

Thesis for the degree of doctor of medicine

Regulation of IL‐6‐signaling and inflammatory response 

‐role of insulin, FOXO1 and PKCδ   

EMELIE WALLERSTEDT   

 

UNIVERSITY OF GOTHENBURG 

The Lundberg Laboratory for Diabetes Research

Center of Excellence for Cardiovascular and Metabolic Research Department of Molecular and Clinical Medicine/Diabetes

The Sahlgrenska Academy at University of Gothenburg 2010

(2)

Regulation of IL‐6‐signaling and inflammatory response 

‐role of insulin, FOXO1 and PKCδ 

EMELIE WALLERSTEDT 

ISBN 978-91-628-8040-8

© 2010 Emelie Wallerstedt

Printed by Intellecta Infolog AB, Gothenburg, Sweden  

Previously  published  papers  were  produced  with  the  permission  from  the  publishers: 

Paper I: This article is reprinted from Andersson CX, Sopasakis VR, Wallerstedt E, Smith  U.  Insulin  antagonizes  interleukin­6  signaling  and  is  anti­inflammatory  in  3T3­L1  adipocytes. J Biol Chem. 2007 Mar 30;282(13):9430‐5. © 2010 by American Society for  Biochemistry and Molecular Biology. Paper II: This article is reprinted from Wallerstedt  E, Smith U, Andersson CX. Protein kinase C­δ is involved in the inflammatory effect of IL­6  in  mouse  adipose  cells.  Diabetologia.  2010  Feb  12.  [Epub  ahead  of  print].  ©  2010  Copyright Clearance Center, Inc. All Rights Reserved. 

(3)

     

Till Pappa

(4)

The picture was drawn by Renata Alvadia, Rio de Janeiro, Brazil, 2008.

References

Download now ( PDF - 4 Page - 177.82 KB )

Related documents

Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states

Department of Clinical and Experimental Medicine Faculty of Health Sciences, Linköping University. se -581 85 Linköping,

Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

2020 In vestigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity | Angela Molinaro. ISBN 978-91-7833-864-1 (PRINT)

Gut microbial regulation of bile acid metabolism and signaling

This effect of the gut microbiota on hepatic bile acid synthesis may be the key point of microbial modulation of bile acid metabolism, the downstream effects of which causes

Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

Here we compared three hepatoma cell lines from three different species: HepG2, human hepatoma, Hepa 1-6, murine hepatoma and McARH7777, rat hepatoma to primary hepatocytes

Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

PI3Kg plays an important role in leukocyte recruitment during inflammation, in the inhibition of classical macrophage activation and in promoting diet-induced obesity and

REGULATION OF IL‐6‐SIGNALING AND INFLAMMATORY RESPONSE ‐ ROLE OF INSULIN, FOXO1 AND PKC δ

Surprisingly, PKCδ was not important for activation of STAT3 signaling and transcription of inflammatory molecules in HepG2 cells since PKCδ knockdown in these

REGULATION OF IL-6-SIGNALING AND INFLAMMATORY RESPONSE -ROLE OF INSULIN, FOXO1 AND PKCδ

Insulin was found to exert an anti-inflammatory effect on IL-6-signaling in 3T3-L1 adipocytes by reducing the tyrosine phosphorylation of the transcription factor

Insulin signaling dynamics in human adipocytes

Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes.