Insulin Signaling in Human Adipocytes a Systems Biology Approach

Insulinsignaleringen i fettcellen är komplex och signalöverföringen inne i cellen sker främst via en kaskad av fosforyleringar, där olika proteiner i en signalkedja fosforyleras

In this thesis, I have focused on insulin signaling in human adipocytes; how these cells become resistant to insulin in type 2 diabetes, and how to connect such intracellular data

vitro and the whole-body in vivo situation. The modeling analysis revealed that the GLUT1 and insulin signaling-enhanced GLUT4 mediated uptake of glucose by isolated human adipocytes

Simulated results are depicted as blue solid lines (one line for each extreme acceptable parameter-set), and experimen- tal data are depicted as red, filled circles with error-bars

Faculty of Health Sciences Linköping University SE-581 85 Linköping, Sweden.

Replace the figure legend with: IQGAP1 distribution in the adipocytes was visualized with a fluoerescent antibody aganinst IQGAP1 using confocal microscopy. The nucleus was stained

Results from my research group have shown that adipocytes from T2D patients have reduced insulin sensitivity for phosphorylation of extracellular signal-regulated kinase (ERK), AS160,

1624, 2018 Department of Clinical and Experimental Medicine Linköping University. SE-581 83