GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

The comparative study of 12-month GH treatment between 15 abdominally obese men and women (Paper III) showed that men are more responsive than women in terms of

We hypothesized that insulin resistance in non-diabetic pa- tients is associated with worse clinical outcome, impaired coronary flow re- serve and peripheral vascular function in

In addition, the ob/ob mice may be a useful translational model for interventional studies to improve understanding of microvascular complications in impaired glucose

The aim of this thesis was to investigate direct proliferative and protective effects of compounds of the GH/IGF-I axis on cells or tissue from organs that are exposed to

Smooth muscle cells (SMC) and endothelial cells (EC), the two major constituents of the vascular wall, are both characterized by the expression of unique phenotypic marker genes,

The results presented herein collectively demonstrate that C/EBPs play pivotal roles in epithelial cell differentiation during lung organogenesis, and that both C/EBPα and C/EBPβ

We hypothesized that ADAR editing of multiple site regions of “hot-spots” would show a pattern of distinct coupled positions since there is an apparent equidistance of edited

Hypoxia inhibits Sima degradation and blocks CRM1-dependent nuclear export, resulting in the nuclear accumulation of Sima and increased transcriptional activity (107).. In