Linköping University medical dissertations
No. 942
On certain genetic and metabolic risk factors for
carotid stenosis and stroke
Pär W. Wanby
Errata
Page 12, Table 3, second line from bottom: “G765C” should be “G -765C” and under “Findings” the text should be: “CC genotype: OR = 0.33 (protective) for myocardial infarction or stroke”.
Page 14, Table 4: a correct version is shown on the back of this list. Page 18, line 8: “An A to a G” should be: “An A for a G”.
Page 21: line 7 of the second paragraph: the reference should be moved to line 6. Page 25, line 11: “T786→C” should be: “T -786→C”.
Page 26, Fig 6: the direction of the arrow between “Tetrahydrofolate” and “Methyltetrahydrofolate” should be the opposite.
Page 28, line 9, “386” should be: “411”.
Page 28, line 21, “the present investigation” should be “Studies I-III”. Page 29, Fig 7: a correct version is shown on the back of this list.
Page 32, line 4 from bottom and in Paper IV, page 11, line 1: “Lidell” should be: “Liddell”. Page 34, Table 7 and 8 are incorrect; for correct tables see Paper I, Table 1 and 2.
Page 49, Fig 9: to the text under the figure, “(n = 263, p = 0.004)” should be added.
Paper IV, page 9, line3: “GAKCCCCAG” should be: “GAKCCCCCAG” and this “C” is also missing in Fig 1a-c (pages 31-33).
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Table 4. Significant associations between gene polymorphisms and carotid IMT/carotid stenosis.
Gene Polymorphism Findings Reference
Matrix metallo-proteinase 3; 5A/6A > carotid IMT in 6A allele Rundek T et al.,
MMP3 ICA stenosis more Ghilardi et al., 2002
frequent in 6A allele
Apolipoprotein E; APOE APOε2, ε3, ε4 > carotid IMT in APOε4 Cattin et al., 1997
APOε4 allele Angiotensin converting enzyme
1; ACE-1
Insertion (I) or Deletion (D)
> carotid IMT in D allele Hosoi et al., 1996 Extracranial artery stenosis Pfohl et al., 1998 stenosis more frequent in
in DD genotype Metylentetrahydrofolate-reductase; MTHFR C677T > carotid IMT in TT genotype Lim et al., 2001
ICA stenosis more Inamoto et al., 2003
frequent in TT genotype genotype
Nitric oxide synthase; eNOS (NOS3)
G984T > carotid IMT in TT
genotype
Paradossi et al., 2004
Fractalkine receptor ; CX3CR1 T280M ICA stenosis less Ghilardi et al., 2004
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Fig 7. Studies I-IV (n=patients and controls).
I.FABP2 in CVD n=565
II. FABP2 in ICA
stenosis n=196 III. ADMA in CVD n=411 IV. FABP2,eNOS and ADMA in ICA stenosis n=108
