Figures from: Exploring the major cross-talking edges of competitive endogenous RNA networks in human Chronic and Acute Myeloid Leukemia

AKN-028 is a potent inhibitor of FLT3 with an IC 50 value of 6 nM in an enzyme assay, but also displaying in vitro activity in a variety of primary AML samples, irrespective of

The primary aim of the present thesis was to investigate the influence of CYP3A metabolic activity and cellular transport mediated by genetic variants of ABCB1 and ABCG2

The thesis work has comprised in vitro studies of interactions between NK cells and primary myeloid leukemic cells along with analyses of NK cell repertoires in a clinical trial

The thesis work has comprised in vitro studies of interactions between NK cells and primary myeloid leukemic cells along with analyses of NK cell repertoires in a clinical trial

The addition of HDC or other ROS inhibitors or scavengers rescued a significant proportion of NK cells (Figure 8B). These results support the hypothesis that

However, NK cells are implicated significant effector cells in several malignancies, including acute myeloid leukemia where the leukemic blasts mostly express HLA class I Paper I,

Additionally, a single nucleotide polymorphism in HLA-B that dictates NK cell inhibition to be preferentially mediated by NKG2A impacted positively on outcome in this trial

In this study we have investigated the effect of HXR9, a peptide designed to inhibit the interaction between HOX proteins and a cofactor, on acute myeloid leukemia (AML) cell lines