Quantitative Magnetic Resonance Imaging of the Brain
Linköping University Medical Dissertations No. 1384
Linköping University Medical Dissertations No. 1384, 2014 Center for Medical Image Science and Visualization
Division of Radiation Physics Department of Medical and Health Sciences Faculty of Health Sciences, Linköping University
SE-581 85 Linköping, Sweden www.liu.se
Janne WestQuantitative Magnetic Resonance Imaging of the Brain2014
Applications for Tissue Segmentation and Multiple Sclerosis
Janne West
Quantitative Magnetic Resonance Imaging of the Brain
Applications for Tissue Segmentation and Multiple Sclerosis Janne West
Quantitative magnetic resonance imaging (qMRI) is aimed at the direct measurement of physical tissue properties. It can be used for brain tissue segmentation as well as for characterising changes in neurological diseases such as multiple sclerosis (MS).
The present work describes a new method of qMRI for the human brain (QMAP), and a segmentation method based on this. The developed met- hods were validated both in control subjects and MR phantoms. In addi- tion, an application for MS patients was demonstrated.
One major finding of this work was that qMRI was able to detect and quanti- fy tissue changes in MS, which were not visible using conventional MRI.
This work also demonstrated that QMAP offered high accuracy and also relatively high precision, within a clinically acceptable examination time.
Furthermore, qMRI could be used for brain tissue segmentation and vo- lume estimation of the whole brain, parameters that may be highly useful in characterising progression in neurological diseases.
The challenge for the future is to understand the connection between the qMRI properties of the brain and underlying biology.
ISBN 978-91-7519-472-1
Quantitative Magnetic Resonance Imaging of the Brain
Linköping University Medical Dissertations No. 1384
Linköping University Medical Dissertations No. 1384, 2014 Center for Medical Image Science and Visualization
Division of Radiation Physics Department of Medical and Health Sciences Faculty of Health Sciences, Linköping University
SE-581 85 Linköping, Sweden www.liu.se
Janne WestQuantitative Magnetic Resonance Imaging of the Brain2014
Applications for Tissue Segmentation and Multiple Sclerosis
Janne West
Quantitative Magnetic Resonance Imaging of the Brain
Applications for Tissue Segmentation and Multiple Sclerosis Janne West
Quantitative magnetic resonance imaging (qMRI) is aimed at the direct measurement of physical tissue properties. It can be used for brain tissue segmentation as well as for characterising changes in neurological diseases such as multiple sclerosis (MS).
The present work describes a new method of qMRI for the human brain (QMAP), and a segmentation method based on this. The developed met- hods were validated both in control subjects and MR phantoms. In addi- tion, an application for MS patients was demonstrated.
One major finding of this work was that qMRI was able to detect and quanti- fy tissue changes in MS, which were not visible using conventional MRI.
This work also demonstrated that QMAP offered high accuracy and also relatively high precision, within a clinically acceptable examination time.
Furthermore, qMRI could be used for brain tissue segmentation and vo- lume estimation of the whole brain, parameters that may be highly useful in characterising progression in neurological diseases.
The challenge for the future is to understand the connection between the qMRI properties of the brain and underlying biology.
ISBN 978-91-7519-472-1