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Atrial fibrillation and cause of death, sex differences in mortality, and anticoagulation treatment in low-risk patients

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Örebro Studies in Medicine 176 I

ÖREBRO 2018 2018

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issn 1652-4063 isbn 978-91-7529-236-6

Atrial fibrillation and cause of

death, sex differences in mortality,

and anticoagulation treatment in

low-risk patients

TOMMY ANDERSSON

Medical Science with a specialisation in Medicine

tommy andersson was born in 1970 and received

his medical degree at Umeå University Hospital in 1999. His internship was performed at Gällivare Hospital. He became a specialist in Internal Medicine 2005 following work at the Department of Medicine in Mora and the Department of Cardiology in Falun. Since 2005, he has worked at the Department of Cardiology, Örebro Uni-versity Hospital and became a specialist in Cardiology in 2007. He has been a part of the arrhythmia unit, primarily working with atrial fibrillation, pacemakers and ICD.

Atrial fibrillation is the most common form of arrhythmia, and around 3% of the population are affected. In this regard, there are concerns rela-ting to when patients with a low risk of cerebral infarction should receive anticoagulants, the causes of death in patients with atrial fibrillation, and whether there are differences in the risk of mortality between the sexes. The studies were based on National Swedish Registries. In considering these questions, this thesis showed, firstly, a benefit of warfarin in patients with AF and 1 point from the CHA2DS2-VASc score due to the age criterion (65-74 years). Secondly, the most common causes of death were cerebral infarction, heart failure and ischemic heart disease. Thirdly, the absolute risk of mortality in AF patients was higher in males compared to females, but the hazard ratio was higher in females than in males when AF patients were compared to same-sex controls.

Doctoral Dissertation

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References

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