Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2

phase of the cell cycle and promoting programmed cell death [92]. The clear potential of ERBB-targeted therapies in the treatment of cancer, has led to development of a variety of

Formyl peptide receptor 2 (FPR2) in neutrophils is such a receptor and plays an important role in inflammation. This thesis focuses on the molecular basis for FPR2 ligand

Paper II investigates a pediatric autoinflammatory syndrome, periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), and demonstrates that

Abstract: The focus for this PhD project has been to investigate neutrophil functions in differ- ent (inflammatory) settings with specific focus on phagocyte-derived

Since then, the number of identified biased ligands is steadily increasing and today functional selectivity most often discrim- inates between G-protein-dependent

II Michael Gabl, Malene Winther, Amanda Welin, Anna Karlsson, Tudor Oprea, Johan Bylund, Claes Dahlgren, Huamei Forsman.. P2Y 2 receptor signaling in neutrophils is regulated

Activation of GPCRs in neutrophils mediates in addition to chemotaxis, also granule mobilization and the generation of reactive oxygen species (ROS). ROS and granule constituents

Activation of GPCRs in neutrophils mediates chemotaxis, but also granule mobilization and the generation of reactive oxygen species (ROS). ROS and granule constituents are not