LINKÖPING UNIVERSITY FACULTY OF HEALTH SCIENCES
DEPT OF CLINICAL AND EXPERIMENTAL MEDICINE DIVISION OF SURGERY AND CLINICAL ONCOLOGY SE-581 85 LINKÖPING, SWEDEN
LINKÖPING UNIVERSITY MEDICAL DISSERTATIONS NO. 1112
Radiotherapy is an important treatment modality, which is given to a majority of patients with breast cancer. It induces different types of DNA damage in affected cells. Double-strand breaks are the most lethal form of DNA damage and, at the same time, the most difficult to repair. The aim of this thesis has been to increase our understanding of the complex mechanisms that control cellular response to DNA damages. A second goal has been to identify biomarkers that can predict the clin-ical response of breast tumours to radiotherapy. Several DNA repair associated proteins, as well as the PI3-K/AKT signalling pathway that promotes cellular survival, have been studied. The work in this thesis contributes new knowledge about the roles of these factors as predic-tors of the outcome of radiotherapy.
DNA
repair pathways and the
effect of radiotherapy
in breast cancer
KARIN SÖDERLUND LEIFLER
KARIN SÖDERLUND LEIFLER
DNA
REP
AIR P
A
THW
LINKÖPING UNIVERSITY FACULTY OF HEALTH SCIENCES
DEPT OF CLINICAL AND EXPERIMENTAL MEDICINE DIVISION OF SURGERY AND CLINICAL ONCOLOGY SE-581 85 LINKÖPING, SWEDEN
LINKÖPING UNIVERSITY MEDICAL DISSERTATIONS NO. 1112
Radiotherapy is an important treatment modality, which is given to a majority of patients with breast cancer. It induces different types of DNA damage in affected cells. Double-strand breaks are the most lethal form of DNA damage and, at the same time, the most difficult to repair. The aim of this thesis has been to increase our understanding of the complex mechanisms that control cellular response to DNA damages. A second goal has been to identify biomarkers that can predict the clin-ical response of breast tumours to radiotherapy. Several DNA repair associated proteins, as well as the PI3-K/AKT signalling pathway that promotes cellular survival, have been studied. The work in this thesis contributes new knowledge about the roles of these factors as predic-tors of the outcome of radiotherapy.
DNA
repair pathways and the
effect of radiotherapy
in breast cancer
KARIN SÖDERLUND LEIFLER
KARIN SÖDERLUND LEIFLER
DNA
REP
AIR P
A
THW