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LINKÖPING UNIVERSITY FACULTY OF HEALTH SCIENCES

DEPT OF CLINICAL AND EXPERIMENTAL MEDICINE DIVISION OF SURGERY AND CLINICAL ONCOLOGY SE-581 85 LINKÖPING, SWEDEN

LINKÖPING UNIVERSITY MEDICAL DISSERTATIONS NO. 1112

Radiotherapy is an important treatment modality, which is given to a majority of patients with breast cancer. It induces different types of DNA damage in affected cells. Double-strand breaks are the most lethal form of DNA damage and, at the same time, the most difficult to repair. The aim of this thesis has been to increase our understanding of the complex mechanisms that control cellular response to DNA damages. A second goal has been to identify biomarkers that can predict the clin-ical response of breast tumours to radiotherapy. Several DNA repair associated proteins, as well as the PI3-K/AKT signalling pathway that promotes cellular survival, have been studied. The work in this thesis contributes new knowledge about the roles of these factors as predic-tors of the outcome of radiotherapy.

DNA

repair pathways and the

effect of radiotherapy

in breast cancer

KARIN SÖDERLUND LEIFLER

KARIN SÖDERLUND LEIFLER

DNA

REP

AIR P

A

THW

(2)

LINKÖPING UNIVERSITY FACULTY OF HEALTH SCIENCES

DEPT OF CLINICAL AND EXPERIMENTAL MEDICINE DIVISION OF SURGERY AND CLINICAL ONCOLOGY SE-581 85 LINKÖPING, SWEDEN

LINKÖPING UNIVERSITY MEDICAL DISSERTATIONS NO. 1112

Radiotherapy is an important treatment modality, which is given to a majority of patients with breast cancer. It induces different types of DNA damage in affected cells. Double-strand breaks are the most lethal form of DNA damage and, at the same time, the most difficult to repair. The aim of this thesis has been to increase our understanding of the complex mechanisms that control cellular response to DNA damages. A second goal has been to identify biomarkers that can predict the clin-ical response of breast tumours to radiotherapy. Several DNA repair associated proteins, as well as the PI3-K/AKT signalling pathway that promotes cellular survival, have been studied. The work in this thesis contributes new knowledge about the roles of these factors as predic-tors of the outcome of radiotherapy.

DNA

repair pathways and the

effect of radiotherapy

in breast cancer

KARIN SÖDERLUND LEIFLER

KARIN SÖDERLUND LEIFLER

DNA

REP

AIR P

A

THW

References

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