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Molecular Biotechnology Programme Alligator Bioscience

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Molecular Biotechnology Programme

Alligator Bioscience

UPTEC X 07 045 Date of issue 2007-06

Author

Therés Gårdenborg

Title (English)

Improvement and characterisation of CHIPS’ affinity towards the C5a receptor

Title (Swedish) Abstract

Chemotaxis Inhibitory Protein of Staphylococcus aureus (CHIPS) is a protein that inhibits migration of neutrophils to the site of infection by binding to and blocking signalling from the C5a receptor. CHIPS may function as an anti-inflammatory therapeutic compound. Screening for CHIPS variants with increased affinity for the C5aR was performed using phage display, followed by sequencing of interesting clones.

Keywords

CHIPS, phage display, Staphylococcus aureus, anti-inflammatory Supervisors

Erika Gustafsson

Alligator Bioscience Scientific reviewer

Staffan Svärd

ICM, Uppsala Universitet

Project name Sponsors

Language

English

Security

ISSN 1401-2138

Classification

Supplementary bibliographical information Pages

30

Biology Education Centre Biomedical Center

Husargatan 3 Uppsala Box 592 S-75124 Uppsala Tel +46 (0)18 4710000 Fax +46 (0)18 555217

References

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