Örebro Studies in Medicine 107 I
ÖREBRO 2014 2014VL
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vladimir t bašic received his first degree of Master of Science with a major in Biochemistry, year 2007 at the University of Novi Sad, Serbia. He received his second degree of Master of Science with a major in Biomedical Laboratory Science, year 2013 at the Örebro University, Sweden. He did his doctoral studies from 2011 to 2014 at the Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Sweden, where he also worked as an assistant in education.
COPD is a fourth leading cause of death and a fifth leading cause of disability worldwide. Development of cachexia syndrome and a consequential deterio-ration of peripheral muscle function significantly associates with increased mortality and reduced life quality in COPD.
An important step towards better management of muscle abnormalities and dysfunction in COPD is to reveal molecular alterations underlying their development and progression. Development of animal models and in-vitro platforms, such as in this study, represents a valuable strategy and a powerful tool to get a better insight into possible mechanisms and pharmacological targets, which can in turn lead towards better treatment of the human disease. This thesis might give a miniature contribution to this goal.
issn 1652-4063 isbn 978-91-7529-031-7
Molecular mechanisms
mediating development of
pulmonary cachexia in COPD
VLADIMIR T BAŠIC
Medical Science with a specialisation in biomedicine
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