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This thesis is based on the following studies, referred to in the text by their Roman numerals.

I. Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes. Peris, E., Micallef, P., Paul, A., Palsdottir, V., Enejder, A., Bauzá-Thorbrügge, M., Olofsson, C.S., Wernstedt Asterholm, I. Journal of Biological Chemistry, 294 (7), pp. 2340-2352 (2019).

II. The adipokine C1QTNF3 is increased in breast cancer-associated adipose tissue and regulates macrophage functionality. Micallef, P., Wu, Y., Peris, E., Wang, Y., Li, M., Chanclón, B., Rosengren, A., Ståhlberg, A., Cardell, S., Wernstedt Asterholm, I. Submitted.

III. Adipose tissue - breast cancer crosstalk leads to increased tumor lipogenesis associated with enhanced tumor progression. Micallef, P., Chanclón, B., Stensöta, I., Wu, Y., Peris, E., Wernstedt Asterholm, I. Manuscript.

This thesis is based on the following studies, referred to in the text by their Roman numerals.

I. Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes. Peris, E., Micallef, P., Paul, A., Palsdottir, V., Enejder, A., Bauzá-Thorbrügge, M., Olofsson, C.S., Wernstedt Asterholm, I. Journal of Biological Chemistry, 294 (7), pp. 2340-2352 (2019).

II. The adipokine C1QTNF3 increases in breast cancer-associated and high fat diet-induced obese subcutaneous adipose tissue, and pushes M2-type macrophages towards an M1-like. Micallef, P., Wu, Y., Peris, E., Wang, Y., Li, M., Chanclón, B., Rosengren, A., Ståhlberg, A., Cardell, S., Wernstedt Asterholm, I. Submitted.

III. Adipose tissue - breast cancer crosstalk leads to increased tumor lipogenesis associated with enhanced tumor growth. Micallef, P., Chanclón, B., Stensöta, I., Wu, Y., Peris, E., Wernstedt Asterholm, I. Manuscript.

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