Linköping University Medical Dissertations, No. 1057
Towards surgical use of matrix
metalloproteinase biology
Björn Pasternak
Thesis at a glance
Elevated MMP-2, -7 and TIMP-2 in patients with a history of Achilles tendon rupture. MMP-7 at three years correlated inversely to early biomechanical parameters of tendon healing. Eight patients with previous
Achilles tendon rupture. Twelve control blood donors. RSA measurement of tendon biomechanics. Serum MMPs and TIMPs.
To compare serum MMPs and TIMPs between patients with a history of Achilles tendon rupture and controls.
To relate levels of MMPs and TIMPs to mechanical parameters of the healing tendon.
IV
Doxycycline-coated sutures improved mechanical strength of intestinal anastomoses. No difference between carrier-coated and uncarrier-coated sutures. Rat colon anastomosis model.
Doxycycline-coated sutures. Biomechanics at 3 days. To investigate the effect
of local MMP-inhibitor doxycycline on intestinal anastomotic healing
III
Systemic and local doxycycline treatment improved tendon suture fixation.
Rat Achilles tendon suture fixation model. Systemic doxycycline and doxycycline-coated sutures. Biomechanics at 3, 5 and 7 days.
To investigate the effect of systemic and local MMP-inhibitor doxycycline on tendon suture fixation
II
Clinically relevant dose of doxycycline impaired tendon healing.
Rat Achilles tendon transection model. Systemic doxycycline. Biomechanical evaluation at 5, 8 and 14 days. Serum concentration of doxycycline. To investigate the effect
of systemic MMP-inhibitor doxycycline on tendon healing I Results Methods Objectives Paper
MMP: matrix metalloproteinase. TIMP: tissue inhibitor of metalloproteinases. RSA: radiostereometric analysis.
Björn Pasternak
Towards surgical use of matrix metalloproteinase biology
Linköping University Medical Dissertations, No. 1057
Towards surgical use of matrix
metalloproteinase biology
Björn Pasternak
Thesis at a glance
Elevated MMP-2, -7 and TIMP-2 in patients with a history of Achilles tendon rupture. MMP-7 at three years correlated inversely to early biomechanical parameters of tendon healing. Eight patients with previous
Achilles tendon rupture. Twelve control blood donors. RSA measurement of tendon biomechanics. Serum MMPs and TIMPs.
To compare serum MMPs and TIMPs between patients with a history of Achilles tendon rupture and controls.
To relate levels of MMPs and TIMPs to mechanical parameters of the healing tendon.
IV
Doxycycline-coated sutures improved mechanical strength of intestinal anastomoses. No difference between carrier-coated and uncarrier-coated sutures. Rat colon anastomosis model.
Doxycycline-coated sutures. Biomechanics at 3 days. To investigate the effect
of local MMP-inhibitor doxycycline on intestinal anastomotic healing
III
Systemic and local doxycycline treatment improved tendon suture fixation.
Rat Achilles tendon suture fixation model. Systemic doxycycline and doxycycline-coated sutures. Biomechanics at 3, 5 and 7 days.
To investigate the effect of systemic and local MMP-inhibitor doxycycline on tendon suture fixation
II
Clinically relevant dose of doxycycline impaired tendon healing.
Rat Achilles tendon transection model. Systemic doxycycline. Biomechanical evaluation at 5, 8 and 14 days. Serum concentration of doxycycline. To investigate the effect
of systemic MMP-inhibitor doxycycline on tendon healing I Results Methods Objectives Paper
MMP: matrix metalloproteinase. TIMP: tissue inhibitor of metalloproteinases. RSA: radiostereometric analysis.
