BISPHOSPHONATES
AND IMPLANTS
IN THE JAW BONE
Linköpings University Medical Dissertations No. 1348, 2013
Linköpings University Medical Dissertations No. 1348, 2013 Faculty of Health Science
Department of clinical and experimental medicine, division of Orthopaedics Department of Oral & Maxillofacial Surgery, University Hospital, Linköping, Sweden
SE - 581 83 Linköping, Sweden www.liu.se Jahan Abtahi 2013
Jahan Abtahi
BISPHOSPHONA
TES AND IMPLANTS IN THE JA
W BONE
Thesis at a glance:
Questions Methods Evaluation Answers I+II Does
bisphosphonate-coating improve the fixation of dental implants?
Clinical implant insertion, Randomized trial Resonance frequency analysis, Radiography Yes
III Can ONJ-like lesions be
reproduced in rats? Tooth extractionDexamethasone Bisphosphonate
Clinical observation
Histology Yes IV Does
bisphosphonate-coating improve implant fixation also under conditions with a high risk of ONJ-like lesions?
Implant insertion In rat ONJ model
Clinical observation Removal torque Micro-CT scan
Yes
V Can ONJ-like lesions be prevented by mucoperiosteal coverage Tooth extraction with immediate coverage in rats Clinical observation Histology Yes
