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BISPHOSPHONATES

AND IMPLANTS

IN THE JAW BONE

Linköpings University Medical Dissertations No. 1348, 2013

Linköpings University Medical Dissertations No. 1348, 2013 Faculty of Health Science

Department of clinical and experimental medicine, division of Orthopaedics Department of Oral & Maxillofacial Surgery, University Hospital, Linköping, Sweden

SE - 581 83 Linköping, Sweden www.liu.se Jahan Abtahi 2013

Jahan Abtahi

BISPHOSPHONA

TES AND IMPLANTS IN THE JA

W BONE

Thesis at a glance:

Questions Methods Evaluation Answers I+II Does

bisphosphonate-coating improve the fixation of dental implants?

Clinical implant insertion, Randomized trial Resonance frequency analysis, Radiography Yes

III Can ONJ-like lesions be

reproduced in rats? Tooth extractionDexamethasone Bisphosphonate

Clinical observation

Histology Yes IV Does

bisphosphonate-coating improve implant fixation also under conditions with a high risk of ONJ-like lesions?

Implant insertion In rat ONJ model

Clinical observation Removal torque Micro-CT scan

Yes

V Can ONJ-like lesions be prevented by mucoperiosteal coverage Tooth extraction with immediate coverage in rats Clinical observation Histology Yes

References

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