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(1)

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

COMPLEMENT ACTIVATION- good or evil in HIV-1 infection?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

Veronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

(2)

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

COMPLEMENT ACTIVATION- good or evil in HIV-1 infection?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

Veronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

COMPLEMENT ACTIVATION

- good or evil in HIV-1 infection?

C O M P L E M E N T A C T IV A T IO N - g oo d o r e vil in H IV -1 in fe cti on ?

Interaction of Free and Complement Opsonized HIV-1 with Monocyte Derived Dendritic Cells and Immune Cells

in the Cervical Mucosa

V

eronica Tjomsland did her PhD at the Department of Clinical and Experimental Medicine, Division of Molecular Virology, under the supervision of Professor Marie Larsson. The aim of this thesis was to understand more about HIV-1 pathogenesis, with focus on how HIV-1 interacts with the dendritic cells (DCs) and the initial HIV-1 infection of DCs and CD4+ T cells in cervical mucosa. We hope that the knowledge gained will contribute to the design of an hope that the knowledge gained will contribute to the design of an effective vaccine or therapy in the future, which is urgently needed with more than 30 million people infected with HIV-1.

The interactions of HIV-1 with DCs and T cells were studied in culture and in a cervical tissue explant model. DCs and CD4+ T cells are the first cell types to come in contact with HIV-1 upon infection. HIV-1 takes advantage of the DCs and uses them for transportation to the lymph nodes where HIV-1 is transferred to its main target cells, the CD4+ T cells. Importantly, at the same time, the DCs present peptide antigens derived from the captured virions on their surface and activate specific T cell responses directed against HIV-1.

Division of Molecular Virology Department of Clinical and

Experimental Medicine Faculty of Health Sciences

SE-581 85 Linköping

References

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