Örebro Studies in Medicine 233 I
ÖREBRO 2021 2021JEN
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jenny seilitz was born in 1978 and raised in Garphyttan, Närke. In 2003, she received her medical degree from Uppsala University and started her internship at Mora Hospital, Dalarna. After a residency in anaesthesia and intensive care, she took up a position in 2011 at the Department of Cardiothoracic and Vascular Surgery at Örebro University Hospital. In 2015, she registered as a PhD student at Örebro University with Kristofer Nilsson, Kjell Jansson, Birger Axelsson and Måns Edström as supervisors. Her research focus has been gastrointestinal function in cardiac surgery patients.
Gastrointestinal complications after cardiac surgery and gastrointestinal failure during intensive care have a substantial impact on outcome. Through human and animal experimental studies, this thesis aimed to investigate means of detecting, grading and avoiding impairment of the gastrointestinal tract after cardiac surgery and during subsequent intensive care, and its association with outcome. Intraperitoneal microdialysis was used to investigate intraabdominal metabolism during and after routine cardiac surgery. In large animal models, the influence of stepwise reduced cardiac output on the metabolism and circulation in the gastrointestinal tract, and the gastrointestinal effects of two inodilators and two vasoconstrictors in fixed low cardiac output, were examined. The oc-currence and consequence of early postoperative gastrointestinal dysfunction in cardiac surgery patients were investigated using the Acute Gastrointestinal Injury grade and a biomarker for enterocyte damage, intestinal fatty acid-binding protein. This thesis provides evidence for an association between intraoperative gastrointestinal injury, postoperative gastrointestinal dysfunction and manifest complications, and that the effects of inodilators and vasoconstrictors must be considered.
issn 1652-4063 isbn 978-91-7529-378-3
