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WP 2 D2.2 : Assessment of cytokine induction and IFN suppression by first set of vaccine candidates

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GA 101003666 Start date: 01/04/20 End Date: 31/03/22

Project Title OPENCORONA

WP number,

deliverable number, and Title

WP 2 D2.2 : Assessment of cytokine induction and IFN suppression by first set of vaccine candidates

Responsible partner

name and contact Partner number: 2 Organisation: JLU

Name: Friedemann Weber

Email: friedemann.weber@vetmed.uni-giessen.de Nature

R-Report P-Prototype D-Demonstrator O=-Other

R

Dissemination level PU-public

PP-restricted to otherprogramme participants

RE-restricted to a group of partners CO-only for

consortium members

PU (to be published)

Delivery Month

Planned 6

Actual delivery date

(dd/mm/yy) 14/10/2020

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003666

1 Ref. Ares(2020)6591228 - 11/11/2020

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Description of deliverable

COMPLETED

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003666

D 2.2: Assessment of cytokine induction and IFN suppression by first set of vaccine candidate.

1. RT-qPCR analyses of the first set of vaccine candidates (cytokine inductions, A549 cells)

1 10 100 1000 10000 100000 1000000

IFN-β mRNA

1 10 100 1000 10000 100000

ISG15 mRNA

1 10 100 1000 10000 100000 1000000

IFN-λ1 mRNA

1 10 100 1000 10000

MxA mRNA

ü slight activation of IFNs and ISGs ü very little cytokine activation

ü inhibition of type I (but not type III) induction and signalling by OC-11 (M alone)

2

(3)

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003666

3

1 10 100

IL-10 mRNA

1 10 100

TNF-α mRNA

1 10 100

IL-8 mRNA

1 10 100 1000

IL-6 mRNA

2. Reporter assays to investigate activation of Tol-like receptors (TLR 2, 3, 4, 7, 8, 9)

(4)

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003666

4

ü Systems have been set up for TLRs 2,3,4,7,8,9 ü No activation of any TLR, not even TLR4

References

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