Advances in the field of bio analysis, primarily in mass spectrometry but also in chromatographic separation, may have led to analytical systems now being sufficiently sensitive
Skillbäck T, Mattsson N, Hansson K, Mirgorodskaya E, Dahlén R, van der Flier W, Scheltens P, Duits F, Hansson O, Teunissen C, Blennow K, Zetter- berg H and Gobom J.. A
Abbreviations Aβ, β amyloid AD, Alzheimer’s disease ADAM, A Disintegrin And Metalloproteinase APOE, Apolipoprotein E APP, amyloid precursor protein AUROC, area under the
When evaluating the diagnostic performance of T-tau and T-tau/P-tau ratio using the test results at the time point closest to death, another 7 CJD patients were classified
The cross-sectional part included an HIV-positive group (n = 252) divided into six subgroups: Four groups of neuroasymptomatic (NA) patients without treatment,
This thesis evaluates biomarkers related to: neuronal injury (neurofilament light chain protein (NFL) and total tau (t-tau)); immune activation (neopterin); and altered
locally 1,5 µl of a TAT-CRE recombinase with a concentration of 4,5 mg/ml (EG-1001, Excellgen; Rockville, U.S.) was directly injected into the right lateral ventricle of mice
Key words: Alzheimer’s disease, cerebrospinal fluid, frontotemporal dementia, neurodegeneration, proteomics, mass spectrometry, prefractionation, protein