APPENDIX S SOD AND DOS STUDIES S-1

(1)

in two views of S2 sod04r02. Table S.2 defines the DOS marker anatomical locations and Figure S.3 illustrates these locations in D5 dos21r01. Table S.3 defines the markers delineating the space-filling tetrahedral for volume calculations. Figures S.4A-F display these tetrahedral within the left atrium and left ventricle of SOD hearts S1, S2, S3, S7, S9, and S10.

Frame Rate = 60 frames/sec (16.667 msec/frame) Each Row in the Datasets is a frame.

ECG Voltage is in Dataset Column 4; LVP in Column #5;

Marker #1X(cm) is in Column 11, #1Y(cm) in Column 12, #1Z(cm) in Column 13; Marker #2X(cm) is in Column 14, #2Y(cm) in Column 15, #2Z(cm) in Column 16; ETC., ETC.

TABLE S.1 SOD MARKER ANATOMICAL LOCATIONS MARKER #’s

Apex 1

Anterior LV Subepicardium 2,3

Septal LV Subepicardium 4,5

High Septal Endocardium 6

Posterior LV Subepicardium 7,8

Lateral LV Subepicardium 9,10

Posterior Papillary Tip 11

Posterior Papillary Base 12

Anterior Papillary Tip 13

Anterior Papillary Base 14

Mitral Annular Septal 22

Mitral Annular Anterior Commissure 16

Mitral Annular Midpoint Between #22 and #16 15

Mitral Annular Lateral 18

Mitral Annular Posterior Commissure 20

Anterior Leaflet Radial Meridian (Annulus to Edge) 23,24,25,26

Posterior (P2) Leaflet Radial Meridian (Annulus to Edge) 28,27

Anterior Leaflet A1 Edge (Paired with #30) 29

Posterior Leaflet P1 Scallop Edge (Paired with #29) 30

Anterior Leaflet P3 Edge (Paired with #32) 31

Posterior Leaflet P3 Scallop Edge (Paired with #31) 32

Septal Left Atrium 33

Posterior Left Atrium 34

Lateral Left Atrium 35

Anterior Left Atrium 36

(2)

(3)

(4)

All datasets in Appendix S have markers suitable for the analysis in Chapter 41, but some have missing markers that could affect other analyses. All markers are present in D1 (dos09r01.1e), D3 (dos12r01.1e), and D5 (dos21r01.1e); some are missing in D2 (dos11r01.1e) and D4 (dos18r01.1e). All markers are present in S1 (sod03r02.1E), S2 (sod04r02.1E), S3 (sod07r01.1E), S7 (sod11r02.1E), S9 (sod12r01.1E), and S10 (sod13r02.1E); some are missing in S4 (sod08r04.1E), S5 (sod09r02.1E), and S6 (sod10r02.1E).

TABLE S.2 DOS MARKER ANATOMICAL LOCATIONS MARKER #’s

Apex 1

Anterior LV Subepicardium 2,3

Septal LV Subepicardium 5,6

High Septal Endocardium 7

Posterior LV Subepicardium 12,13

Lateral LV Subepicardium 9,10

Posterior Papillary Tip 23

Posterior Papillary Base 24

Anterior Papillary Tip 25

Anterior Papillary Base 26

Mitral Annular Septal 22

Mitral Annular Anterior Commissure 16

Mitral Annular Lateral 18

Mitral Annular Posterior Commissure 20

Anterior Leaflet Radial Meridian (Annulus to Edge) 31,32,33,34

Posterior (P2) Leaflet Radial Meridian (Annulus to Edge) 36,35

Anterior LV subendocardium (Paired with #3) 28

Septal LV subendocardium (Paired with #6) 27

Posterior LV subendocardium (Paired with #13) 30

Lateral LV subendocardium (Paired with #10) 29

Septal Left Atrium 8

Posterior Left Atrium 14

Lateral Left Atrium 11

(5)

(6)

TETRAHEDRON

T1

M#1

M#2

M#7

M#9

T2

M#1

M#2

M#4

M#7

T3

M#5

M#2

M#4

M#7

T4

M#5

M#2

M#3

M#7

T5

M#5

M#8

M#3

M#7

T6

M#10

M#8

M#3

M#7

T7

M#10

M#2

M#3

M#7

T8

M#10

M#2

M#9

M#7

T9

M#3

M#5

M#6

M#8

T10

M#6

M#15

M#21

M#22

T11

M#3

M#6

M#15

M#21

T12

M#3

M#6

M#20

M#21

T13

M#3

M#6

M#8

M#20

T14

M#15

M#20

M#21

M#22

T15

M#3

M#20

M#10

M#15

T16

M#3

M#8

M#10

M#20

T17

M#15

M#19

M#10

M#20

T18

M#15

M#19

M#10

M#18

T19

M#15

M#17

M#10

M#18

T20

M#15

M#17

M#10

M#16

T21

M#15

M#16

M#10

M#3

T22

M#19

M#20

M#10

M#8

SOD ATRIAL TETRAHEDRON

P1

P2

P3

P4

T1

M#21

M#22

M#20

M#33

T2

M#15

M#22

M#20

M#33

T3

M#15

M#19

M#20

M#33

T4

M#15

M#19

M#18

M#33

T5

M#15

M#17

M#18

M#33

T6

M#15

M#17

M#16

M#33

T7

M#19

M#20

M#34

M#33

T8

M#19

M#18

M#34

M#33

T9

M#17

M#18

M#34

M#33

T10

M#17

M#18

M#34

M#35

T11

M#17

M#33

M#34

M#35

T12

M#17

M#33

M#36

M#35

T13

M#17

M#33

M#36

M#16

T14

M#15

M#33

M#36

M#16

T15

M#19

M#34

M#35

M#18

T16

M#37

M#33

M#36

M#34

T17

M#37

M#35

M#36

M#34

(7)

Figure S.4B S2 space-filling tetrahedra Figure S.4A S1 space-filling tetrahedra

(8)

Figure S.4F S10 space-filling tetrahedra Figure S.4E S9 space-filling tetrahedra