Regenerative effects of mesenchymal stem cell-derived exosomes

External signals triggers the transcriptional machinery Provides switch behaviour. - Genetic network architecture

ES cell specific proteins, like Oct4, have been reported to be expressed in certain human tumors 25 , and embryonic gene expression patterns were shown to become

(A) Immunocyto- chemical staining for bIII tubulin (Alexa Fluor 488) visualized neurite outgrowth (highlighted with arrows) from SH-SY5Y cells following 24 h co-culture with medium

Keywords: aging, cell adhesion, cell-material interaction, exosomes, extracellular vesicles, mesenchymal stem cells, osteogenic differentiation, proliferation,

The findings presented in this thesis demonstrate the regenerative effects of MSC-derived EVs/exosomes, in terms of stimulating proliferation, osteogenic differentiation,

In paper IV we found that MSCs up-regulated their gene expression of BMP2 and RUNX2 in response to signal secreted from LPS- activated MO and in paper V it

Keywords: Mesenchymal stem cells, mesenchymal stromal cells, osteogenic differentiation, adipogenic differentiation, bone regeneration, inflammation, monocytes,

We observed no immunosuppression in mice pretreated with natural EVs, whereas MSCs and CIMVs-MSCs suppressed antibody production in vivo.. Additionally, we have investigated