Örebro Studies in Medicine 167 I
ÖREBRO 2017 2017FR
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issn 1652-4063 isbn 978-91-7529-215-1Perioperative complications
in obese patients
A thesis on risk reducing strategies
FREDRIK ANDER
Medical Science with a specialization in Surgery
fredrik ander was born in Lidköping, Sweden in 1978.
He received his M.D. degree in 2005 at Uppsala Univer-sity. In 2008 he started his training in anesthesiology and intensive care at Örebro University Hospital and became a specialist in 2013. This doctoral thesis was carried out under the supervision of associate Professor Lars Berggren, PhD. Rebecca Ahlstrand, PhD. and Alex de Leon, PhD. at Örebro University Hospital.
Aspiration of gastric content, prolonged and failed intubation, and airway ob-struction with subsequent hypoxia are the most common causes of anesthesia-related morbidity and mortality. The number of obese patients suffering these complications is disproportionally high. The aim of this doctoral thesis was therefore to see if the use of a videolaryngoscopic intubation technique could shorten the time required for intubation and reduce the incidence of failed intubation. Other aims were to see if the beta-receptor antagonist esmolol, affect the tone of the esophagogastric junction, if low-dose esmolol has an analgesic effect, and whether the intraoperative administration of esmolol instead of remifentanil can reduce the requirement of postoperative rescue treatment with morphine. With the information gained from the experimen-tal and clinical studies in this thesis, new knowledge in this field has been contributed.
