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Surface bound bisphosphonate for implant fixation in bone

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Linköping University Medical Dissertations No. 1059

Surface bound bisphosphonate for implant

fixation in bone

Rat experiments with a novel coating technique

Karin Wermelin

Clinical and Experimental Medicine Department of Medical and Health Sciences

Linköping University, Sweden Linköping 2008

Surface bound bisphosphonate for

implant fixation in bone

Rat experiments with a novel

coating technique

Linköping University Medical Dissertations No. 1059

Surface bound bisphosphonate for implant

fixation in bone

Rat experiments with a novel coating technique

Karin Wermelin

Clinical and Experimental Medicine Department of Medical and Health Sciences

Linköping University, Sweden Linköping 2008

Paper nr Hypothesis Position Analysis Answer

I Does the effect of the bisphosphonate coating increase over time?

Cortical &

cancellous Pullout strength Yes II Is the bisphosphonate coating

technique applicable on titanium screws?

Cancellous Pullout strength Yes

II What is the release profile of

the coated bisphosphonate? PBS solution measurement Scintillation 60 % released within 8 h III Why was the effect of the

bisphosphonate coating increased over time?

Cortical Histomorphometry Formation of a bone “nut” III Does the bisphosphonate

coating increase the removal torque at 2 weeks?

Cancellous Removal torque Yes

IV Does the bisphosphonate coating increase the mechanical fixation in ovariectomized rats too?

Cancellous, ovx

& sham Pullout strength Yes

Karin W

ermelin

Surface bound bisphosphonate for implant fixation in bone -

Rat experiments with a novel

(2)

Linköping University Medical Dissertations No. 1059

Surface bound bisphosphonate for implant

fixation in bone

Rat experiments with a novel coating technique

Karin Wermelin

Clinical and Experimental Medicine Department of Medical and Health Sciences

Linköping University, Sweden Linköping 2008

Surface bound bisphosphonate for

implant fixation in bone

Rat experiments with a novel

coating technique

Linköping University Medical Dissertations No. 1059

Surface bound bisphosphonate for implant

fixation in bone

Rat experiments with a novel coating technique

Karin Wermelin

Clinical and Experimental Medicine Department of Medical and Health Sciences

Linköping University, Sweden Linköping 2008

Paper nr Hypothesis Position Analysis Answer

I Does the effect of the bisphosphonate coating increase over time?

Cortical &

cancellous Pullout strength Yes II Is the bisphosphonate coating

technique applicable on titanium screws?

Cancellous Pullout strength Yes

II What is the release profile of

the coated bisphosphonate? PBS solution measurement Scintillation 60 % released within 8 h III Why was the effect of the

bisphosphonate coating increased over time?

Cortical Histomorphometry Formation of a bone “nut” III Does the bisphosphonate

coating increase the removal torque at 2 weeks?

Cancellous Removal torque Yes

IV Does the bisphosphonate coating increase the mechanical fixation in ovariectomized rats too?

Cancellous, ovx

& sham Pullout strength Yes

Karin W

ermelin

Surface bound bisphosphonate for implant fixation in bone -

Rat experiments with a novel

References

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