Örebro Studies in Medicine 151 I
ÖREBRO 2016 2016SR
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sravya sowdamini nakka graduated with a Bachelor of Technology (Biotechnology) degree from Anna University, Chennai, India in 2009 and thereafter obtained a Master of Science (Molecular Genetics and Physiology) degree from Linköping University, Linköping, Sweden in 2011. She did her Master’s thesis at PEAS Institut AB, Linköping University, Sweden and thereafter continued her doctoral studies in colla-boration with Örebro University, Örebro, Sweden since 2013. Sravya received her Licentiate Degree in Medical Science with specialization in Biomedicine in October 2015.
Periodontitis is a biofilm-induced chronic inflammatory disease leading to destruction of tooth supporting tissues and alveolar bone loss. The etiology of periodontitis depends on a complex interaction of host immune cells with pe-riodontal pathogens that have outnumbered the non-pathogenic microflora in subgingival biofilm. Porphyromonas gingivalis is a late colonizer and modulates host immune responses to favor growth and survival of the entire oral biofilm.
P. gingivalis can strategically invade gingival epithelial cells and infect underlying
tissues. The initial interaction of P. gingivalis with the epithelium integrates both innate and adaptive immune responses to clear the infection. Several inflammatory mediators, such as cytokines and chemokines are secreted to attract immune cells to the site of infection. An exaggerated immuno-inflammatory condition at the gingival crevice leads to tissue degradation. In this thesis, we focus on developing and elucidating the role of novel tools for detection, prevention and treatment of
P. gingivalis infection and periodontitis.
issn 1652-4063 isbn 978-91-7529-162-8
