Örebro Studies in Medicine 100 I
ÖREBRO 2014 2014SAN
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sanja farkas studied at Örebro University and received a Degree of Licentiate with a major in Chemistry in 2009. Since June 2010 she is working as a Clinical Biochemist at the Department of Laboratory Medicine, Örebro University Hospital.
In complex diseases like cancer and neural tube defects (NTD), various genetic and epigenetic alterations can be found that disrupt the normal cell function. Global changes in DNA methylation and gene-specific hypermethylation are key events that underlie the disease development. The main goals of this thesis were to analyze whether the genes responsible for the folate transport (FOLR1, PCFT, and RFC1) could be regulated by DNA methylation in placenta, blood leukocytes and colorectal cancer. We also addressed the genome-wide DNA methylation changes in colorectal cancer and cervical cancer.
issn 1652-4063 isbn 978-91-7668-986-8
