Immunization Approaches and Molecular Signatures for Mucosal Immunity to Primary and Recurrent Genital Herpes

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In this thesis we have identified two new potent mucosal adjuvants for induction of immunity against genital HSV-2 infection, the glycosphingolipid alpha-galactosylceramide

By employment of genome-wide gene expression microarray analysis combined with a bioinformatics approach we assessed the molecular signatures of two classes of

More specifically the model gives an understanding of the in vivo experimental observation of drug target resistance masking, where drug target binding affinity differences do not

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In addition, while rectal immunization with the TLR/MyD88 targeting adjuvant CpG ODN in combination with gD failed to elicit protective immunity, rectal immunization with

Key words: BRAF, NRAS, MGMT, methylation, pyrosequencing, microarray technology, gene expression analysis... I feel so extraordinary Something’s got a hold on me I get this

Proliferative responses after recall stimulation of PBMC from immune donors, patients or vaccinees increased with increasing antigen concentrations and were significantly higher