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Neuropsychological outcomes and health-related quality of life of children operated for nonsyndromic craniosynostosis

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Göteborg, 2021

SAHLGRENSKA AKADEMIN

Neuropsychological outcomes and health-related quality of life of children operated for

nonsyndromic craniosynostosis

Akademisk avhandling

Som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin, Göteborgs universitet kommer att offentligen försvaras i hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, fredagen den 30 april 2021, klockan 09.00 av Marizela Kljajić

Fakultetsopponent:

Erik Domellöf, Docent Umeå universitet, Sverige

Avhandlingen baseras på följande delarbeten

I. Kljajić M, Maltese G, Tarnow P, Sand P, Kölby L. The Cognitive Profile of Children with Nonsyndromic Craniosynostosis. Plastic and Reconstructive Surgery 2019; 143:5, 1037-1052.

II. Kljajić M, Maltese G, Tarnow P, Sand P, Kölby L. Sustained attention and vigilance of children treated for sagittal and metopic craniosynostosis. Child Neuropsychology 2020; 26:4, 475-488.

III. Kljajić M, Maltese G, Tarnow P, Sand P, Kölby L.

Children Treated for Nonsyndromic Craniosynostosis Exhibit Average Adaptive Behavior Skills with Only Minor Shortcomings. Plastic and Reconstructive Surgery 2021; 147:2, 453-464

IV. Kljajić M, Maltese G, Tarnow P, Sand P, Kölby L. Health-related quality of life of children treated for nonsyndromic craniosynostosis. Submitted.

INSTITUTIONEN FÖR KLINISKA VETENSKAPER

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Göteborg, 2021

ISBN 978-91-8009-246-3 (PRINT)

ISBN 978-91-8009-247-0 (PDF) http://hdl.handle.net/2077/67336

Neuropsychological outcomes and health-related quality of life of children operated for

nonsyndromic craniosynostosis

Marizela Kljajić

Avdelningen för plastikkirurgi, Institutionen för kliniska vetenskaper, Sahlgrenska akademin, Göteborgs universitet, Sverige, 2021.

Abstract

The primary aim of this thesis was to assess the intelligence quotient, attention function, adaptive behavior skills, and health-related quality of life of children operated for non- syndromic craniosynostosis. The secondary aim was to evaluate whether surgical meth- ods for treating sagittal synostosis were related to the outcomes. The participants were tested using a range of psychological tests, including The Wechsler Intelligence Scale for Children 4

th

Edition (WISC-IV), The Conners Continuous Performance Test 3

rd

Edi- tion (CPT-3), Adaptive Behavior Assessment System 2

nd

Edition (ABAS-II), and Pedi- atric Quality of Life Inventory (PedsQL) Generic Module. Seventy-three children oper- ated for nonsyndromic craniosynostosis participated in studies I, III, and IV, and 65 children operated for sagittal or metopic synostosis participated in study II. The results revealed average levels of intelligence quotient, attention skills, adaptive behavior skills, and health-related quality of life, and that the surgical methods used to treat sag- ittal synostosis were unrelated to lower or higher outcomes. Furthermore, the findings of this thesis suggest that children treated for nonsyndromic craniosynostosis exhibit average neuropsychological function and good health-related quality of life.

Keywords: nonsyndromic craniosynostosis, neuropsychological functioning, adaptive

behavior skills, health-related quality of life

References

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