Insulin signalling in human adipocytes –mechanisms of insulin resistance in type 2 diabetes

The overall aim of this thesis was to investigate the microcirculation in insulin resistance, with focus on the expression of endothelin-1, through a translational approach.

In support of this idea: (1) replacement of Ser-307 with alanine reduced insulin-stimulated phosphorylation of S6K and DNA synthesis (158); (2) incubation of adipocytes with

Department of Clinical and Experimental Medicine Faculty of Health Sciences, Linköping University. se -581 85 Linköping,

Brist på eller otillräcklig effekt av insulin leder till att detta upptag blir för litet med förhöjt blodsocker som följd. Insulin förhindrar

In this thesis, I have focused on insulin signaling in human adipocytes; how these cells become resistant to insulin in type 2 diabetes, and how to connect such intracellular data

Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes.

Treating cells with β-cyclodextrin (β-CD) results in cholesterol depletion of the membrane and flattening of the caveolae invaginations [135, 140]. In rat adipocytes the

1624, 2018 Department of Clinical and Experimental Medicine Linköping University. SE-581 83