Risk assessment of chemical mixtures in the aquatic environment

Risk assessment of chemical mixtures in the aquatic

environment

-

ABSTRACT

1.2.3

3

250 50 10075 125150 175

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Million Tonnes

Significant Acute Effects Significant Chronic Effects Severe Chronic Effects Chronic Effects

Moderate Chronic Effects

4

𝑃𝑁𝐸𝐶 =min⁡(𝐸𝑓𝑓𝑒𝑐𝑡⁡𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛) 𝐴𝑠𝑠𝑒𝑠𝑠𝑚𝑒𝑛𝑡⁡𝐹𝑎𝑐𝑡𝑜𝑟

1.2.3

𝑅𝐴𝐶 =𝐸𝑓𝑓𝑒𝑐𝑡⁡𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 𝐴𝑠𝑠𝑒𝑠𝑠𝑚𝑒𝑛𝑡⁡𝐹𝑎𝑐𝑡𝑜𝑟

𝑃𝑁𝐸𝐶 = 𝐻𝐶05⁡(50%𝑐.𝑖.) 𝐴𝑠𝑠𝑒𝑠𝑠𝑚𝑒𝑛𝑡⁡𝐹𝑎𝑐𝑡𝑜𝑟

0.00 0.25 0.50 0.75 1.00

0.001 0.01 0.1 1

Rank

µmol/L

𝑅𝑖𝑠𝑘⁡Quotient⁡ =𝐸𝑛𝑣𝑖𝑟𝑜𝑛𝑚𝑒𝑛𝑡𝑎𝑙⁡𝐶𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 𝐸𝑛𝑣𝑖𝑟𝑜𝑛𝑚𝑒𝑛𝑡𝑎𝑙⁡𝑇ℎ𝑟𝑒𝑠ℎ𝑜𝑙𝑑⁡

𝑅𝑄𝐶𝐴= ⁡_𝐸𝐶𝑥^{𝑐𝑚𝑖𝑥}

𝑚𝑖𝑥= ∑ _𝐸𝐶𝑥^𝑐𝑖

𝑖

𝑛𝑖=1 = ⁡ ∑𝑛 𝑇𝑈𝑖 𝑖=1

1

1 n

i Mix

i i

ECx p

ECx





 

  





𝐸(𝑐_𝑚𝑖𝑥) = 1 − ∏ (1 − 𝐸(𝑐^𝑛_{𝑖=1 𝑖}))

𝑅𝑄𝑡𝑜𝑡= ∑ _{𝑃𝑁𝐸𝐶}^{𝑃𝐸𝐶𝑖}

𝑖 𝑛𝑖

RQ_tot= PECA

PNEC_A+ PECB

PNEC_B= 2 (3500

1000)

+ 2.5 (3500

1000)

= 1.3

RQAlgae= PEC_A

EC50Algae+ PEC_B

EC50Algae= 2

12000+ 2.5

3500= 0.0009 RQ_AI= PECA

EC50_AI+ PECB

EC50_AI= 2

7000+ 2.5

7000= 0.0006 RQ_Fish= PECA

EC50Fish+ PECB

EC50Fish= 2

3500+ 2.5

12000= 0.0007

RQ_STU= max(RQ_Algae, RQ_AI, RQ_Fish) ∗ AF = 0.0009 ∗ 1000 = 0.9



 ⁿ

i Crustaceens

i

MST EC EC EC

RQ PEC

1 min( 50Algae, 50 , 50Fish)

 

n i

TUi

MCR RQ

...

1

max





0%

20%

40%

60%

80%

100%

Response

Concentration

Response 1 Response 2 Response 3

Table 5: The average risk contribution per compound, number of compounds and total estimated risk for the hypothetical mixture defined in table 4 for the worst-case, KM and best- case scenario.

0 0.2 0.4 0.6

0 0.2 0.4 0.6 0.8 1

Toxic Unit

Percentile

0 0.2 0.4 0.6

0 0.2 0.4 0.6 0.8 1

Toxic Unit

Percentile

0 0.2 0.4 0.6

0 0.2 0.4 0.6 0.8 1

Toxic Unit

Percentile

3

0.00 0.25 0.50 0.75 1.00

100 1000 10000 100000

Rank

NOEC/EC10 [ng/L]

0.00 0.25 0.50 0.75 1.00

100 1000 10000 100000

Rank

NOEC/EC10 [ng/L]

-5 -4 -3 -2 -1 0 1 2 3 4 5

-5 -3 -1 1 3 5

Log(EFSA environmental threshold)

Log(WQO) WQO

>EFSA Thresholds EFSA Thresholds

>WQO

Swedish WQO more protective

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