Filamin A in Cardiovascular Remodeling

Using a gene-trapping technique our group generated a mouse model of FLNB deficiency that was used in this project in order to test the hypothesis that reduced filamin expression

In addition, platelet membrane-induced ASMC proliferation is 5-LOX and NADPH-oxidase dependent (paper III). In summary, the results obtained in paper I-IV suggest that platelet/HA

Mechanisms involved in platelet-induced fibroblast and airway smooth muscle cell proliferation in vitro. Ann-Charlotte

In mice with elevated adiponectin levels, AAA development was inhibited, and this was associated with reduced inflammatory cell infiltration, reduced medial degeneration

to identify novel treatment strategies and drug candidates.. Targeting vascular remodeling in abdominal

Similarly, we observed reduced foam cell formation in calpeptin-treated macrophages, as well as the specific inhibition of STAT3 signaling by 5,15 DPP-treated macrophages

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With special emphasis on atrial fibrillation, hypertension and diabetes. Linköping University Medical