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Hugo Lagercrantz, you have not only been my main supervisor but also inspired me to continue studies in the medical field. You have been a true supporter when I have had to go through tough times at work. Important to every scientist is to establish connections in the field and outside. As my boss, you have had trust in me and pushed me to also

approach some of the most influential and important scientists of the field today. I hope that I may benefit from your knowledge as a senior advisor in my future research.

Fredrik Setterwall, without your inspiration and ideas this PhD project and Medical Cooling Sweden AB would not have been started. You also from the start wanted me to attend conferences in the energy field, so we could have personal contacts with the

frontline of the PCM field. When you suddenly left us, I realized that we had so much more to talk about and to experience together in the medical and chemical technology fields.

Ulrika Ådén, everyone who has ever worked with you probably feels the same: Under your wings one learns to respect science for what science is and becomes, one learns to fly. And you have always have clever ideas about how to improve research.

Viktoria Martin, your knowledge in the field of material physics has been of great importance. I hope we can continue to work together to implement PCM to save energy consumption and improve hypothermia treatment globally.

Dagmar Galter, without you I would have been a terrible scientist without any reliable neurohistology data. I have always felt that I could discuss science from more than one perspective with you.

Karin Lundströmer, my coauthor, you have been an excellent teacher of the different techniques used in the lab, as well as a great technician. Without your skills to section and process the brain tissue, the group around me would not have such nice results as we do today.

Åke Seiger, I can only say I’m still so happy that you accepted to be my external mentor, no one can have a better one, knowledgeable in the field and a great supporter and friend.

You always give me new inputs as well as positive energy.

Lars Olson, my dad, my discussion partner, a super scientist who has taken me through this great journey and helped me getting some of the best scientific contacts in the world together with Hugo and Fredrik. Thanks also for all the comments to everything I have written in the past and in the future.

Nicola J. Robertson, thank you for being a great friend, top scientist, great collaborator and for all your great science and results this thesis is built upon.

Carina Lothian, Medical Cooling Sweden AB, and the follow up project would not survive with out you, and thanks for believing in me even though I was not a MD.

Viveca Karlsson, Thank you for always being there. You have taught me so much.

Marco Bartocci, a top clinician and co-author as well as a true friend and the person who got me to start playing again what I love most in sports; Basketball.

The rest of the NEO-Cool group: With professor Mats Blennow, the always smiling Dr. Boubou Hallberg, our aEEG specialist Katarina Grossman, the neurologist for follow-ups Birgitte Vollmer, and the nurses who kept us on track Ingela Edqvist and Petra Östberg.

Jacob Carlsson, my ALB room mate, a true scientist, MD, co-author and golf friend.

Gordana Printz, Stuart Faulkner,Manigandan Chandrasekaran,Takenori Kato, Gennadij Raivich, Sachico Iwata, Osuke Iwata, Andrew Kapetanakis, Samantha

Evans, Y Araki, T Kakuma, T Matsuishi, for being such good co-authors with a lot of great ideas and inspiring thoughts on PCM, and our research.

Björn Westrup, Ann Edner, for believing in me and my PCM idea and for asking all the time: when can we start using it.

Eva Lundberg, Ruth Detlofson, the Dept of Women’s and Children’s Health Neonatal Research Unit could be renamed Ruth, Eva and the neonatal PhD students’ experiments' health. Thanks for getting along and taking care of another demanding PhD-student.

Karin Pernold, Eva Lindquist, the Olson lab would not be the same highly efficient and effective lab without you two.

Barry Hoffer, my American super scientific teacher. Not only for making me understand that results are important, but that one also needs social, negotiation, political, and grant application skills to be successful. Thanks also to all of Barry’s different collaborators like Mike Palmer who tried to get me into science much earlier than I my self understood, for my own best.

Joyce Hoffer, all people need to have role-models. In science imaging is getting more and more important, you gave me a base to grow from. In life, another important base.

Rose Lagercrantz, your insightful and warm advice has meant a lot to me.

Ida Engqvist, the IT guru of Karolinska Institutet, for all your wise help.

Mikael Norman, Baldvin Jonson, Eva Berggren-Broström, (and Mats Blennow) with the neonatal staff. Working in such an invigorating world with many inspiring characters and problems to be solved, has been wonderful, and a true contribution to this thesis.

John Bonsib, Mats Arving, your creative minds are such an inspiration And John you have made me think twice about decisions to throw away ideas without exploring them.

And most importantly, be nice to others and they will return the favor, but don’t oversell the product unless you really believe in it, then do.

Astrid Häggblad and the FUK committee at the Dept of Women’s and Children’s Health for their suggestions and many laughs when discussing new PhD student registrations.

Stein Jonsson, Ulf Broberger, Roland & Britt-Marie Bojfeldt, you all got me to want to start playing golf again, and I did, but so far I havn’t been able to beat any of you, but now when my thesis is over…But also to do great work done, the body needs exercise and oxygen and pleasant discussions for a few hours.

Miles and Barbara Davies, without your push in how to be a trustful person when applying for grants and in commercial life, who knows how I would have survived economically.

Gary Cohen, Miriam Katz-Salamon, Thank you both from the bottom of my heart and lungs.

Fellow PhDs and PhD-students, Zachi Horn, Panos Papachristou, Johan and Linda Jäderstad, Beatrice Skiöld, Georgios Alexandrous, Max Winerdal, Sophia Savage, Fredrik Sterky, Caroline Ran, Sandra Gellhaar, Tobias Karlsson, Anna Gunnebäck, Anna Anvret, Johanna Sundblad, Cicci Dyberg, Anna Kock, Jenny Dahlström, David & Josephine Forsberg, Lisette Grae, Hanna Ingelman-Sundberg, Emöke Deischman, Jaime Ross, Adam Sierakowiak, Jacob Kjell, Lea Forsman, Veronica Siljehav, Jenny Bolk, Alexander Rakow

Edstedt-Bonamy, Anna Mattsson, Andrea Carmine Belin, Elin Åberg, Helena Martin, Sofia Yderberg, Stefan Brené for important discussions over coffee.

Nurses and teachers and past room mates, Veronica Berggren, Ann-Sofi Ingman, Birgitta Viksten, Ann Carlsson

Research nurses, Lena Swartling, Emilija Wilson, Lena Legnevall

Anna Josephson, you have been supporting me as a person and inspired me to study harder and to take courses, even letting me occupy some space (and even borrow your desk at work), encouraging others to do the same.

Janet Hidalgo, Marah Dinola, for believing in me as Linus but also for not wanting me to play a role. And other important persons from abroad, thank you for letting me be a slow responder, so that I would dedicate more time and work as a scientist.

Dagmar Olson, Sorry for every other scientist, I have the best mother a scientist can have, a critical, sophisticated, widely knowledgeable in the medical field, funny, supporting, and understanding one.

Andreas Henschen, to have an uncle who knows how it is to be a PhD student, as well as to be a neonatalogist dedicated to work and with experience of having been employed by researchers with many creative solutions similarly dedicated to work, has been great and fun. But most of all encouraging.

Lisa & Tomas Thiel, Johannes Thiel & Annica Waltersson, Måns Olson, a scientist needs to have family support as well as professional support. You five have given me both, Statistics, Medicine, Databases, Computer games, Illustrations and design, and Computers in general.

Fanny, Lova, Signe, Villemo, you all inspired me more than you understand for the moment. But the four of you are the future of the world.

Aunts, Uncles, Cousins, and their significant others, I say like the Mafioso: Family is everything.

The KI Toronto exchange course with all partcipants and Ola Hermanson: I hope you all will keep being my friends and collegues for many years to come. And that we may in different forms explore the scientific fields together.

Friends outside working enviroment, Wow, the crazy scientist in your mind is now meetable again.

And to everyone else, you are not forgotten, just not mentioned: From the bottom of my heart, Thank You all.

The thesis work was supported by:

Stiftelsen Barncentrum, Sällskapet barnavård, Vinnova, Lindhe-fonderna, Kronprinsessan Lovisas stiftelse, Märtha Lundqvists stiftelse, Stiftelsen Frimurare, Barnhuset i Stockholm, the Swedish Brain Foundation, Swedish Brain Power, the Swedish Research Council, Torsten och Ragnar Söderbergs Stiftelser, and the Karolinska Institutet.

Other:

Medical Cooling Sweden AB, (conflict of interest: Linus Olson is a shareholder; the company has filed a patent for PCM.), Live Now Under Strength, Nice HB, Trientalis AB, Siemens Elema, Datex, Know IT, Denver medical school and University College of London.

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