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47 for helping me to choose the wedding dress during the time you were still working on your thesis.

To all my scientific collaborators: Catharina Larsson, thanks for your great input and all the constructive comments to paper II. You are also such a kind person that I can discuss about anything with you. Sonia Andersson, thanks for generously providing us with cervical tumor samples which makes paper II happen. Susanne Muller, thanks for your dedication to paper II and I enjoyed the time working with you. Wish you all the best as a doctor! Weng-Onn Lui, your tremendous knowledge in RNA filed is a great contribution to paper I and paper IV.

Enormous thanks to all my dear lab members! Susanne, for all your tremendous help during all these years. You are strict about rules in the lab, which I understand as the only way to maintain everything in right order and I also know you have a soft heart. Qiang, Mei, Emarndeena, for your help in the lab and all the great dinner time and salsa dancing time we have spent together. Emarn, life in lab will be so boring without you and your songs! Mei, it is so exciting that we are expecting our babies together! Sophia, thanks for your help with the fantastic figures for our manuscript and my thesis kappa.

Check her company “ceder graphic” out of if you need any help on figures. Sofi, Fredrik, Helene and Julie, the post-doc work force and currently the great Wig-1 team! J I see a bright future of our Wig-1 field with all of your efforts. Vladimir, you impressed all of us with your broad knowledge from molecular biology to engineering. You are a genius who can fix no matter a broken iblot or an old HPLC. We can come to you to seek for help for not only FACS data analysis or statistical analysis, but also any other technical problems. Mireia, you are fresh blood in the lab. Keep working hard and you will achieve your goal. Harsha, although you are working in MTC, you are still my lab member, thanks for your support.

Thierry Soussi, it is our great honor to have you joining our lab meetings and sharing lots of interesting journals with us. Thanks for providing constructive suggestions to my research. Your immense knowledge in p53 field has greatly broadened my horizon.

Marianne Farnebo, thanks for your encouragement and scientific comments to me on the kick-offs. To previous and present members of Farnebo’ group: Salah, Elisabeth and Sofia, we used to have lab meetings and kick-offs together and thanks for all the inspirations I got from you. Hanif, great thanks to you for helping me at the last minute with taking immunostaining pictures by your skilled confocal technique! Thanks Soniya, Christos, Stefanie, Chiara for the enjoyable lunch chatting in the kitchen!

Chunde Li, thanks for being such a kind person and for giving me helpful advices. The crew in Li’ group, previous and present members: Peng Zhuochun, Ma Yuanjun, it is my great pleasure to have you as my friends and hope we continue our friendship in the future. And also Liu Yanling, thanks for your help.

Leonard Girnita, I really appreciate your help when I need a sponsor for my abstract for the AACR conference.

The remaining lab colleagues and friends in CCK R8:04: Andrew, you are always kind and willing to help. Thanks for your great help on immunocytochemistry. The way you

48 keep everything well organized impressed me a lot! Wang Na, Lin Yingbo, Dudi, I enjoyed the chatting time we had at lunch and sincerely appreciate all of your support and help and we will keep in touch. Roger, you are excellent at organizing the RNA club.

Keep rolling and wish you achieve your goals in life. And also thanks Omid, Satendra, Wen-Kuan for your help.

All my colleagues and friends from CCK: Ma Ran & Chen Xinsong, it is nice to meet you both and become friends with you. We have seen each other through ups and downs and I have never stopped receiving help and encouragement from you. Zhang Xiaonan

& Zou Fan, it is lots of fun to spend time together with you. I have always appreciated your positive attitudes and kindness to friends sounding you. You will be great parents!

Mao Yumeng, a brilliant guy with great sense of humor. Wish you a bright future!

Nikolaos, I enjoyed all the pleasant chats with you when I came down to use the Nano-drop. Johanna, Sara, Lisa thanks for your kind help whenever I need. Zhang Yuanyuan, Wang Xin, Ma Limin, Guo Min, Yu Rong all the pretty and sweet girls, you made my daily life in CCK more enjoyable. And big congratulations to Shen Xianli for your nature paper coming soon!

I would like to thanks for all the administration staff for your great help: Erika, Susanne, Sören, Monica, Maria, Ann-Britt, Eva-Lena, Elisabeth and Elle. And also Inger, thanks for teaching me the immunohistochemistry technique. Juan, thanks for your kind help with the FACS data analysis.

The previous CCK colleagues and friends: Xie Hong, you are a skilled and diligent scientist. I bother you a lot, but you are always glad to help. Wish you great success in China. Pinar, we had lots of fun in San Diego. Wish you good luck with your new life in Gothenborg. Zheng Huiyuan & Liu Tong, thanks for your help and inviting me to the wonderful dinner at your place. Sylvia, Mehdi, Cecilia, good luck with your scientific career in the new labs.

Thanks for all my friends’ supports from KI: Han Hongya, Miao Xinyang, Song Jianren, Guan Na, Zhu Jianwei, Song Huan, Zhuang Ting, Zhu Jian, Zhu Linjing, Huang Zhangshen, Lou Daohua, Du Kai, Xiao Qin, Yang Dong, Rui Wang, Yan Qinzi, Ren Xiaoyuan, Huang Jiaqi, Ji Jie, Wang Jingwen. Thanks to Guo Jing and Jiang Xia for helping me with the high-through put data analysis with your profound statistical skills.

My friends from the badminton group: Thanks Song Jie, Yao Liqun, Li Xin, for helping me out during my wedding time. Jie, iceland trip with you was a lot of fun. Zhang Qiong, Hu Wei, Wan Feng, Xuan Yang, Zhang Yuning, Cao Bo, Zhang Wenjie, Liu Xuejin, Chang Peiliang, Wang Tongmei, Li Shuijie, Wang Yiqiao, Li Xiaofei, Tang Xiao, I enjoyed all the happy time we have spent together!

I appreciated the friendship established in Stockholm with Wang Jinsong & Lei Min, for those pleasant holidays at your place. Xie Shanshan, Zhang Cheng, Zhang Qian, Chen Lei, Wang Zhao, Yang Yanpeng, Javier and Tatiana, Kristin for your support and companies. Shi Feng, thanks for hosting me when I was travelling in Norway.

49 Those friends left Sweden and now in China or USA: Luo Jiangnan, Sun Chengjun, Sun Tianyang, Gu Tianwei, Zou Hongyan, Huang Genping, Li Xichen, Liu Yanfang, Wang Dongcheng, Wei Wei, Wei Xueqiong, Cen Jinkang, wish you all the best and soon we will reunion for sure!

Su Lujing, we became penfriends since we met in the summer school in Zhejiang University. It is amazing that we have our friendship until now. We have a lot in common and understand each other well. You have always been supportive and helpful to me over years! Wish you happy in Germany! Zhu Hong, Xiao Jue, thanks for our long lasting friendship and your support!

致我亲爱的家人(to all my family members)

非常感谢我的爸爸妈妈,你们无私的爱和奉献是我坚强的后盾,你们的理解和支 持让我能追逐自己的梦想,你们的宽容和鼓励使我更加独立自信,我永远爱你 们!

奶奶,你永远是家族的纽带和精神寄托,希望你长寿。感谢我的至亲们,你们 对我的关心和支持是我持续不断前进的动力,希望你们都安康幸福。作为一个独 生子,最幸运的是拥有众多关系融洽的表/堂兄弟姐妹!非常感谢你们的陪伴!

特别是从小一起长大的表妹钦钦,希望我们像小时候通信时说的那样,白发苍苍 的时候,还能经常坐在藤椅上一起喝茶聊天。

亦将此文献给求学期间故去的外婆,略补未尽孝道和未见最后音容之憾,你对我 的关爱是永恒而深远的,希望你在天堂安详。

致我亲爱的夫君芃,芃的爸爸妈妈和爷爷奶奶

徐妈妈和张爸爸,感谢你们生养了芃,也感谢你们像对待女儿一样关心爱护我。

爷爷奶奶你们放心,我们会互爱,互敬,互勉,互慰,互让,互谅,互助,互 学。

芃,跟你在一起的日子特别开心,特别自在。据说最好的伴侣是可以激发内心中 最好的自己,我觉得你比认识我以前更好了呢,啊,当然,我也是。你了解我时 常的不理智和冲动,宽慰我实验挫败后的郁闷心情,接受我的坏脾气和习惯性迟 到。你总是一如既往地支持我,陪伴我,你的宽容你的逗比你的精湛厨艺统统都 是我的药。

我们可爱的小麦麦,真等不及要见到你,爸爸和妈妈都很爱你!

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