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UPTEC X 04 019 ISSN 1401-2138 MAR 2004

ANDREAS BERNSEL

Analysis of SNP microarray data using the rough

set approach

Master’s degree project

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Molecular Biotechnology Programme

Uppsala University School of Engineering

UPTEC X 04 019 Date of issue 2004-03 Author

Andreas Bernsel

Title (English)

Analysis of SNP microarray data using the rough set approach

Title (Swedish)

Abstract

New methods for association analysis based on Rough Set theory were developed and successfully applied to both simulated and biological genotype data. An estimation of the significance level of the results was assessed through a randomization procedure. The results here confirm earlier findings of two Single Nucleotide Polymorphisms (SNPs) possibly associated to Systemic Lupus Erythematosus (SLE). Additionally, one new SNP was found which might be significantly associated to SLE.

Keywords

SNP, minisequencing, association analysis, Systemic Lupus Erythematosus, machine learning, rough set, rough modeling

Supervisors

Ann-Christine Syvänen

Department of Medical Sciences, Uppsala university Scientific reviewer

Tomas Axelsson

Department of Medical Sciences, Uppsala university

Project name Sponsors

Language

English

Security

ISSN 1401-2138 Classification

Supplementary bibliographical information

Pages

51

Biology Education Centre Biomedical Center Husargatan 3 Uppsala

Box 592 S-75124 Uppsala Tel +46 (0)18 4710000 Fax +46 (0)18 555217

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