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Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease

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Design and Synthesis of Inhibitors

Targeting BACE-1, an Aspartic Protease

Involved in the Pathogenesis of

Alzheimer’s Disease

Veronica Sandgren

Linköping Studies in Science and Technology, Dissertation No. 1436, 2012

Ve ro ni ca S an dg ren D esi gn a nd S ynt he sis o f I nh ibito rs T arg etin g B AC E-1 , a n A sp art ic P rot ea se I nv olv ed i n t he P ath og en esi s o f A lzh eim er’s D ise ase

2

012

Linköping Studies in Science and Technology No. 1436, 2012 Department of Physics, Chemistry and Biology

Organic Chemistry Linköping University SE-581 83 Linköping

Veronica Sandgren was born in Ransta, Sweden, on January 30, 1981, to AnnBritt Sandgren and Kenneth Johansson. She graduated from Linköping University in 2004 with a Master of Science in Chemistry. In 2006, she began her postgraduate studies in Organic Chemistry under Professor Ingemar Kvarnström and Professor Bertil Samuelsson.

(2)

Design and Synthesis of Inhibitors

Targeting BACE-1, an Aspartic Protease

Involved in the Pathogenesis of

Alzheimer’s Disease

Veronica Sandgren

Linköping Studies in Science and Technology, Dissertation No. 1436, 2012

Ve ro ni ca S an dg ren D esi gn a nd S ynt he sis o f I nh ibito rs T arg etin g B AC E-1 , a n A sp art ic P rot ea se I nv olv ed i n t he P ath og en esi s o f A lzh eim er’s D ise ase

2

012

Linköping Studies in Science and Technology No. 1436, 2012 Department of Physics, Chemistry and Biology

Organic Chemistry Linköping University SE-581 83 Linköping

Veronica Sandgren was born in Ransta, Sweden, on January 30, 1981, to AnnBritt Sandgren and Kenneth Johansson. She graduated from Linköping University in 2004 with a Master of Science in Chemistry. In 2006, she began her postgraduate studies in Organic Chemistry under Professor Ingemar Kvarnström and Professor Bertil Samuelsson.

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