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Molecular Biotechnology Programme

Uppsala University School of Engineering

UPTEC X 14 022 Date of issue 2014-08 Author

Maya Salomonsson

Title (English)

Exploring innate type B cells in an animal model for autoimmune arthritis

Title (Swedish) Abstract

B cells have a central role in the pathogenesis of collagen-induced arthritis (CIA), an animal model of the autoimmune disease rheumatoid arthritis. In this report, a specific subset of an innate type of B cells, B-1 B cells, have been studied for the involvement in CIA. The B-1 B cells were shown to produce small amounts of collagen-specific antibodies upon stimulation in vitro, suggesting that they play a minor role in the development of CIA. This report also includes how marginal zone B cells, another innate type of B cells with natural collagen- reactivity, can be identified in the medullary sinuses of lymph nodes of collagen-immunized mice, implying involvement in auto antigen trapping.

Keywords

Rheumatoid arthritis, collagen-induced arthritis, B-1 B cells, MZB, MZBL, antibodies,

polyreactive antibodies, collagen-specific antibodies, MACS, FACS, ELISA, ELISPOT, IHC.

Supervisor

Sandra Kleinau, Uppsala universitet Scientific reviewer

Lars Hellman, Uppsala universitet

Project name Sponsors

Language

English

Security

ISSN 1401-2138 Classification

Supplementary bibliographical information

Pages

28

Biology Education Centre Biomedical Center Husargatan 3 Uppsala

Box 592 S-75124 Uppsala Tel +46 (0)18 4710000 Fax +46 (0)18 471 4687

References

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