Structural biology of transcriptional regulation in the c-Myc network

A super-enhancer, recently termed as blood enhancer cluster (BENC) and conserved between mice and humans,.. This BENC is crucial for both normal hematopoiesis and leukemia

Thelander, The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle-regulated

Translation initiation regulation is generally part of the global control of protein synthesis where the phosphorylation state of initiation factors and regulatory proteins

Translation initiation is impaired in response to stress in sty1 cells and the Atf1 transcription factor, which is a known target for Sty1 contributes to translation recovery

To understand Myc evolution and its role in cancer, we used the intrinsic disorder profile of Myc family proteins as a signature to analyze their structural evolution, as well as the

Moreover, while specific SOX2 binding reflects the distinct gene expression patterns of each region where it is detected, common SOX2 bound CRMs are found around genes involved

It has been shown that these transcription factors when overexpressed in the chick developing spinal cord, block neuronal differentiation and maintain progenitor

Dysfunction of the UPS and/or ubiquitin presenting proteins has been reported to reduce skeletal muscle atrophy (Caron et al. 2011) and induce muscle growth defects