Signaling and Adhesive Mechanisms in Acute Pancreatitis Awla, Darbaz

LUND UNIVERSITY PO Box 117 221 00 Lund +46 46-222 00 00

Awla, Darbaz

2011

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Citation for published version (APA):

Awla, D. (2011). Signaling and Adhesive Mechanisms in Acute Pancreatitis. [Doctoral Thesis (compilation), Surgery]. Lund University.

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1

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Mechanisms in Acute Pancreatitis

Darbaz Awla

Academic Thesis

With permission from the Medical Faculty at Lund University for the presentation of this PhD thesis in a public forum in MFC, Entrance 59, Skåne University

Hospital, Malmö, on Friday 9^th December 2011 at 13:00.

Faculty Opponent: Professor Matthias Löhr, Karolinska Institute

Lund University

Faculty of Medicine

Department of Clinical Sciences-Malmö, Section of Surgery Skåne University Hospital 2011

Mechanisms in Acute Pancreatitis

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Abbreviations ««««««««««««««««««««««««« 9

Original papers «««««««««««««««««««««««« 11 Additional papers ««««««««««««««««««««««« 12 Introduction «««««««««««««««««««««««««« 13 Background «««««««««««««««««««««««««« 14

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Inflammation««««««««««««««««««««««««« 19

Leukocyte recruitment««««««««««««««««««««« 19 /HXNRF\WHUROOLQJ««««««««««««««««««««««« 

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Chemokines «««««««««««««««««««««««««« 22

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Signaling pathways««««««««««««««««««««««« 

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Matrix metalloproteinases (MMPs)«««««««««««««««« 26 003««««««««««««««««««««««««««« 

Aims««««««««««««««««««««««««««««« 29

Materials and Methods«««««««««««««««««««««« 31 ([SHULPHQWDOGHVLJQ«««««««««««««««««««««« 

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Conclusions«««««««««««««««««««««««««« 45

Sammanfattning på svenska««««««««««««««««««« 47 Acknowledgements««««««««««««««««««««««« 51 References««««««««««««««««««««««««««« 53

Papers

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List of original papers

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his PhD but which are not included in this thesis

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