Correlation Transfer in Striatal Network via Morphology Changes

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IN

DEGREE PROJECT COMPUTER SCIENCE AND ENGINEERING, SECOND CYCLE, 30 CREDITS

STOCKHOLM SWEDEN 2020,

Correlation Transfer in Striatal Network

via Morphology Changes

LIHAO GUO

KTH ROYAL INSTITUTE OF TECHNOLOGY

SCHOOL OF ELECTRICAL ENGINEERING AND COMPUTER SCIENCE

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λ b, w ρ p

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D1 D2 network in the striatum

Cortex

FSI D2 MSN D1 MSN

GPe TA

TI

GPi

STN SNr

JCF

J_C1 JC2

J11 J22

J21 J12 J_{F 1}

JF 2

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R_a Ohm/cm Cm µF /cm²

gL S/cm²

V_L mV

VP mV

VS mV

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Jc1, Jc2

pr

pb

NdM SN

NiM SN

N_{CT X} Jc1

Jc2

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b, p, λin

(λ, ρ)

f_intrinsic : a_in(λ_in, b, w)→ aout(λ_out, ρ_out) fintrinsic

w

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λ b

b b

w

b ain

ain(λin, b, w)

λout, ρout λout

ρout

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w b

λout ρout

λout

ρout

λout = count(s_i(t)) T

ρ_out = coincidence(s1(t), s2(t))

!coincidence(s1(t), s1(t))∗ coincidence(s²(t), s2(t))

s_i(t)

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pr

p_b

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f_intrinsic λin, b, w ρout, λout

(b, w, λin, Nsyn)

b w

b, w λin

λ_in Nsyn

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(b, w, λin, Nsyn)

λin λout

b|w b|w λ_in pr|p^b

pr

pr = 0.1 pb

pb = 0.5

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pr = 0.1 pb = 0.5

i

j (i, j)

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fM : ain(λin, b, w)→ a^out(λout, ρout) M

λout

λin b, w

b, w λout

fM

λ_in f_M : a_in(b, w)→ aout(λ_out, ρ_out) fM

f_M : a_in(b, w)→ aout(λ_out) fM : ain(b, w)→ aout(ρout) λout

ρout

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λout

λ_out λout− w

ρ_in

λout− w

λout w

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λout

λout − w

λout−w

λout

ρout b w

b w

(b, w) ρout

b w (b, w) ρ"in(b, w)

"

ρ_in(b, w) = b

b∗ w +_N¹(1− b ∗ w) +O 1 N

"

ρout

"

ρout

λout

fM

fp : ain(λin, b, w)→ a^out(λout, ρout)

p p = pr

p = pb

f_p λout ρout

p (λout, ρout)

p

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ρout

ρout b, w

ρout ρout

b, w λout ρout

ρout

Jc1 Jc2

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"

ρ_in(b, w) ρ_out

λout ρout

λ_out, ρ_out

λout, ρout

λ_out

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λout ρout

Jc1, Jc2 λout

λ_in, b, w

pr ρout

λout ρout

λout, ρout

b, w λout

ρout

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b, w b, w

λout, ρout

λin, b, w

b, w b, w

λout, ρout

pr λout, ρout

λout

ρout p ρout

pr

λout, ρout

ρout

ρout pb

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b, w

λout, ρout

pr= 0.0 pr = 0.02

pr

λout ρout

λin, b, w

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b, w

λ_out, ρ_out

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λout, ρout

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λ_out, ρ_out

λout ρout

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pr

λout ρout

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TRITA -EECS-EX-2020:857

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