Örebro Studies in Sport Sciences 28 I
ÖREBRO 2018 2018M
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mattias folkesson is a researcher in Sport Science at the School of Health Sciences at Örebro University. He earned his Degree of Master of Education for the Upper Secondary School in Physical Education, Mathematics and Physics at Örebro University in 2002. Mattias is currently a lecturer at the School of Health Sciences and a part of the Metabolism, Inflammation & Physical Activity (MIPA) research group at Örebro University.
Physical exercise is accompanied by changes in mechanical and metabolic demands and is considered as an important stressor responsible for concerted molecular and cellular changes leading to adaptions at the level of skeletal muscle size and function. An important protein family engaged in the cellu-lar response to exposure from stressful conditions is the heat shock proteins (HSPs). Currently, knowledge on the involvement of different HSP members in the adaptations to specific exercise modalities remains limited.
The present thesis explored the expression of four different HSPs (αB-crystallin, HSP27, HSP60 and HSP70) in human skeletal muscle exposed to exercise (acute/chronic) with a special emphasis on the role of HSP27 in the exercise-induced muscle growth. A muscle fibre type-specific as well as an exercise modality-specific expression of some HSPs together with an acute response of HSP27 immediately after a single bout of resistance exercise were demonstrated. The development of an in-vitro model for the study of the role of HSP27 during the growth of muscle cells indicated that HSP27 is not mandatory for the hypertrophy of human muscle cells. Overall, the present thesis clarified the expression of different HSPs in human skeletal muscle and provided an in-vitro based approach for the elucidation of the exact role played by HSPs in the adaptations of human skeletal muscle to exercise.
issn 1654-7535 isbn 978-91-7529-260-1
