Tendon Healing
Mechanical Loading, Microdamage
and Gene Expression
Linköping University Medical Dissertation No. 1609
Malin Hammerman
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FACULTY OF MEDICINE AND HEALTH SCIENCES
Linköping University Medical Dissertation No. 1609, 2018 Department of Clinical and Experimental Medicine Linköping University
SE-581 83 Linköping, Sweden
www.liu.se
Tendon Healing
Mechanical Loading,
Microdamage
& Gene Expression
Malin Hammerman
Linköping University Medical Dissertation No. 1609
M
al
in H
am
m
er
m
an
Ten
do
n H
eal
in
g
-M ec han ical Lo adi ng, M icr odam age & Ge ne E xpr es sio n20
18
FACULTY OF MEDICINE AND HEALTH SCIENCES
Linköping University Medical Dissertation No. 1609, 2018 Department of Clinical and Experimental Medicine Linköping University
SE-581 83 Linköping, Sweden www.liu.se
Question Methods Evaluation Answer
I Yes
II
III Yes
IV Yes
V Yes
Can moderate loading improve tendon healing?
Which genes are affected by moderate loading?
Which genes are affected by full loading?
Does full loading increase blood leakage?
Is inflammation affected by full loading during the
inflammatory phase of tendon healing?
Is inflammation affected by full loading during the early remodeling phase of tendon healing?
Can microdamage by needling stimulate tendon healing? Is the gene response similar to mechanical loading?
Does COX-2 inhibitor impair the stimulatory effect of
mechanical loading during tendon healing? Is it via mechanotransduction? Is it via microdamage? Extracellular matrix genes Extracellular matrix and inflammation genes Yes No Yes No Yes Thesis at a glance
Tendon Healing
Mechanical Loading,
Microdamage
& Gene Expression
Malin Hammerman
Linköping University Medical Dissertation No. 1609
M
al
in H
am
m
er
m
an
Ten
do
n H
eal
in
g
-M ec han ical Lo adi ng, M icr odam age & Ge ne E xpr es sio n20
18
FACULTY OF MEDICINE AND HEALTH SCIENCES
Linköping University Medical Dissertation No. 1609, 2018 Department of Clinical and Experimental Medicine Linköping University
SE-581 83 Linköping, Sweden www.liu.se
Question
Methods
Evaluation
Answer
I Yes
II
III Yes
IV Yes
V Yes
Can moderate loading improve tendon healing?
Which genes are affected by moderate loading?
Which genes are affected by full loading?
Does full loading increase blood leakage?
Is inflammation affected by full loading during the
inflammatory phase of tendon healing?
Is inflammation affected by full loading during the early remodeling phase of tendon healing?
Can microdamage by needling stimulate tendon healing? Is the gene response similar to mechanical loading?
Does COX-2 inhibitor impair the stimulatory effect of
mechanical loading during tendon healing? Is it via mechanotransduction? Is it via microdamage? Extracellular matrix genes Extracellular matrix and inflammation genes Yes No Yes No Yes
