Carboligation using the aldol
reaction
A comparison of stereoselectivity and methods
Derar Al-Smadi
Chemistry department-BMC
Uppsala University
Errata list:
Page: 23/ Figure 16
OH
MeO
DMSO/O
Cl
Et3N, CH2Cl2O
MeO
20 % 35 36cCl
O
Page: 11
In recent years, “stereochemistry, dealing with the three-dimensional behavior of chiral molecules, has become a significant area of research in modern organic chemistry. The concept of stereochemistry can, however, be traced as far back as the nineteenth century. In 1801, the French mineralogist Hauéy noticed that quartz crystals exhibited hemihedral phenomena, which implied that certain facets of the crystals were exposed as nonsuperimposable species showing a typical relationship between an object and its mirror image. 3 In 1809, the French physicist Malus, who also studied quartz crystals, observed that they could