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Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI

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Linköping University Medical Dissertations No. 1196

Quantitative Evaluation of

Contrast Agent Dynamics in Liver MRI

Nils Dahlström

Center for Medical Image Science and Visualization Division of Radiological Sciences

Department of Medicine and Health Sciences Linköping University, Sweden

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Center for Medical Image Science and Visualization Division of Radiological Sciences

Department of Medicine and Health Sciences Linköping University, Sweden

Linköping 2010

Contrast-enhanced magnetic resonance imaging (MRI) is a comprehensive non-invasive method for discovering and characterizing disease processes in the liver and the biliary system. The gadolinium-based liver-specific contrast agents Gd-BOPTA and Gd-EOB-DTPA enhance blood vessels and the extracellular space, but are also taken up by liver cells (hepatocytes) and excreted into the biliary system. This thesis evaluates the biliary, hepatic parenchymal and vascular en-hancement effects of these contrast agents in MRI of healthy subjects and patients with hepatobiliary disease, using semi-quantitative assessment and quantitative pharmacokinetic analysis.

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