Stimulation of tendon repair by platelet concentrate, cdmp-2 and mechanical loading in animal models
Olena Virchenko
Olena Virchenko Stimulation of tendon repair by platelet concentrate, cdmp-2 and mechanical loading in animal models
Linköping University Medical Dissertations No. 1005
Thesis at a glance
Paper
number Hypothesis Method Conclusion
I PC injection improves
tendon repair 296 rats. Achilles PC, PPP or saline 8, 11, 14, 21 or 28 days Mechanics, histology
PC improves healing. Strength and stiffness increased. Better histological maturation II Thrombin and platelets
stimulate tendon repair independently
60 rats. Achilles
Platelet gel, PC ± thrombin, thrombin alone or saline 14 days. Mechanics
All treatments improve healing compared with saline
III Mechanical stimulation and PC treatment interact
130 rats. Achilles Activity cages, Botox PC or platelet gel 3, 5 or 14 days. Mechanics
Loading is a requirement for stimulation by PC
IV Thromboprophylaxis
impairs tendon repair
86 rats. Achilles
Fragmin injections or mini pumps 7 days
Mechanics, anti-factor Xa activity
LMWH delays healing with continuous treatment, but not with intermittent injections
V CDMP-2 injection
improves tendon repair in a load-protected model
40 rabbits. Unloaded Patellar tendons CDMP-2
14 or 28 days
Mechanics, histology and radiology
A single CDMP-2 injection improves healing. No bone or cartilage formed
VI CDMP-2 injection
improves Achilles tendon repair in sheep
20 sheep. Achilles 100 Pg of CDMP-2 21 days
Mechanics, histology and CT
Large variation and no significant findings. No bone or cartilage formed
