Örebro Studies in Medicine 63
örebro 2011
Doctoral Dissertation
Ultraviolet Light A (UVA) Photoactivation of Riboflavin
as a Potential Therapy for Infectious Keratitis
Karim Makdoumi
Medical Science with focus on Surgery
2011
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Karim maKdoumi M.D. was born in Umeå, Sweden. He
earned his medical degree from the Karolinska Institute, Stockholm in 2003 and subsequently completed his training to become an Ophthalmologist at the Örebro University Hospital. Dr. Makdoumi currently practices as an Ophthalmic Surgeon. During the training period to become a Specialist he was introduced to the procedure of UVA-riboflavin Collagen Crosslinking (CXL) and was gradually involved in a project to evaluate the procedure as a treatment for corneal infections.
The thesis comprised here analyzed different aspects of the photoactivaton of vitamin B2 by ultraviolet light, implemented in CXL, as a therapy for microbial keratitis. Different parameters that are of importance for the antimicrobial effect of the process were investigated in two experimental articles. Furthermore, two clinical studies were conducted, including a retrospective case series of severe infections treated by the method as well as a prospective clinical pilot study to evaluate the efficacy of the photochemical procedure.
Results from the laboratory and clinical investigations, indicate that the photooxidative method can be utilized as an adjuvant treatment in infections. issn 1652-4063 isbn 978-91-7668-834-2
