Linköping University Medical
Dissertation No. 1502
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Metaphyseal Fracture Healing
Olof Sandberg
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Faculty Of Medicine and Health Sciences
Department of Clinical and Experimental Medicine
Linköping University
SE-581 83 Linköping, Sweden
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Question
Methods
Evaluation
Answer
I How do metaphyseal
fractures heal? Biopsy from 12 patients 5 to 26 days after fracture Osteoid forming freely in marrow without cartilage II Can we quantify
metaphyseal healing with a screw?
The force required to pull out the screw depends on amount of bone formed III Is the response to
alendronate different in metaphysis and diaphysis?
Both heal better, metaphysis more so
IV What about the
response to NSAIDs? As above As above Diaphyseal healing impeded, metaphysis less affected V What about to
glucocorticoids? Is stability a factor?
As above + As above Diaphysis impeded, metaphysis slightly improved. No effect of stability VI Are macrophages required for cancellous healing? Yes
VII How do immune cells respond to cancellous or cortical trauma?
Similarly day 3. Day 5 granulocytes increase in cancellous and lymphocytes in cortical
