Protocol name Current version number Protocol version (date) Status Opened (date) Closed (date)
AT/RT EU-RHAB 5.0 2016-12-08 Interim guidelines NA
Choroid plexus carcinoma 0 NA NA No protocol? SIOP CPT 2000? NA NA
CNS Germ cell tumors SIOP CNS GCT II 3.0 2015-11-05 Closed/Interim guidelines 2016? 2018-07-01
DIPG BIOMEDE (or INFORM) 6.0 2018-11-28 Closed/Interim guidelines 2020-08-07
Ependymoma SIOP Ependymoma II 3,1 2020-04-22 Pending
ETMR/CNS-PNET 0 NA NA No protocol (HIT?) NA NA
HGG 0 NA NA Interim guidelines NA NA
Craniopharyngeoma 0 NA NA Published guidelines NA NA
LGG SIOP LGG 2004 1.0 2004, corr jan 2006 Interim guidelines 2004? 2012-04-23
LGG + NF1 SIOP LGG 2004 1.0 2004, corr jan 2006 Interim guidelines 2004? 2012-04-23
Medulloblastoma HR HIT-MED guidance 5.1 2020-08-01 Interim guidelines NA
Medulloblastoma relapse MEMMAT 2.0 2018-02-14 Open 2018-07-13
Medulloblastoma SR/LR SIOP PNET 5 MB 12.0 2015-06-11 Open 2015-09-07
Medulloblastoma Young Children HIT-MED guidance 5.1 2020-08-01 Interim guidelines NA
Pineoblastoma HIT-MED guidance 5.1 2020-08-01 Interim guidelines NA
Meningeoma CCEG or EANO guidelinesNA NA Published guidelines (CCEG) NA NA
Upcoming protocols Protocol name Version Protocol date Status
Future Medulloblastoma Young Children Low risk SIOP YC MB LR Upcoming/Pending
Future Medulloblastoma Young Children High risk SIOP YC MB HR Upcoming/Pending
Future Medulloblastoma HR SIOP HR MB 2.0a 2019-06-05 Upcoming/Pending 2021 (in UK), pending application in Sweden
Future LGG + NF1 SIOP NF-1 LGG Upcoming/Pending
Future LGG SIOP LOGGIC Upcoming/Pending
Future AT/RT SIOP ATRT 01 Upcoming/Pending
Interim guidelines, comment Reporting (Y/N) Randomization (Y/N) Swedish national representative/PI
No? No Clary Georgantzi
No Vacant
See letter 180702 from study group Yes (follow up) No Anders Öberg
Sirolimus (alt. everolimus)+ RT No Yes Klas Blomgren
Use standard arms in protocol When open When open Helena Mörse
No No Elizabeth Schepke
RT/TMZ/CCNU (Jakacki et al 2016) No No Stefan Holm
Guidelines No No Bengt Gustavsson
Use standard arms in protocol No Yes (Per-Erik Sandström) Pernilla Grillner
Use standard arms in protocol No No (Per-Erik Sandström) Pernilla Grillner
No No Magnus Sabel
Amendment 3.0 pending Yes No Magnus Sabel
LR arm closed (temporarily, pending amendment 13) Yes Yes (SR), Not LR Magnus Sabel
No No Magnus Sabel
No No Elizabeth Schepke
Szychot et a. 2020, (adults Goldbrunner et al. 2016) NA NA NA Randomization Swedish PI
Magnus Sabel Magnus Sabel
2021 (in UK), pending application in Sweden Yes Magnus Sabel
Pernilla Grillner
Yes Pernilla Grillner
EU-RHAB Yes Clary Georgantzi
