Molecular Biotechnology Programme Uppsala University School of Engineering

In this degree project Sortase A from Staphylococcus aureus was explored and potential inhibitors were investigated by performing enzyme activity and bacterial binding assays. A

The characterized genes showed gradual improvement and divergence of functions, supporting the Innovation-Amplification-Divergence model of

Moreover, by applying a molecular clock, it is proposed that the Domestic cat lineage has experienced several expansions representing domestication and/or breeding

It showed large dynamic range, no measureable non-specific binding and high sensitivity (with linear range around 0.1 – 10 µg/ml depending on the proteins). The method

Escherichia coli, 23S rRNA, Post-transcriptional modification, In vitro, Peptidyl transferase centre, domain V, Methylation, Pseudouridine, Reverse

The fibrinolytic enzyme tissue type plasminogen activator (t-PA) is released by the vascular endothelium to limit the growth of blood clots and ultimately prevent the occurrence of

investigate the presence of P4 in the brain, in neuromuscular junctions and in adrenal glands, the colocation between P4 and VAChT respectively P4 and VMAT and the possibility that P4

The information obtained by using these algorithms could contribute to the development of new drugs by generating new ligands that target specific high-energy , unfavorable